anti-MSK2, pAb

CHF 322.00
In stock
YIF-LF-PA0051100 µlCHF 322.00
More Information
Product Details
Synonyms MSK2; RSKB; RPS6KA4; S6K-α-4; EC=2.7.11.1; Ribosomal Protein Kinase B; Ribosomal Protein S6 Kinase α-4; 90 kDa Ribosomal Protein S6 Kinase 4; Nuclear Mitogen- and Stress-activated Protein Kinase 2
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application

Western Blot (1:2,000)
IHC-P
Immunoprecipitation not tested.

Crossreactivity Human
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Mitogen- and stress-activated protein kinases (MSK2) is nuclear kinase that act downstream of mitogen-activated protein/extracellular signal-regulated kinase pathways. It contains two kinase domains in the N-terminal and C-terminal region, respectively. MSK2 is activated in response to mitogenic stimuli via Erk1/2MAPK pathway and also by stress stimuli via p38MAPK pathway. Signals from mitogens and cellular stresses are involved in many functions including cell proliferation, differentiation, and survival through the phosphorylation of cyclic AMP response element-binding protein (CREB) at Ser133 which is catalyzed by MSK2. Recently, MSK2 has been shown to be required for stress-induced phosphorylation of histone H3-Ser and transcriptional activation of several immediate early genes. Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional activation of several immediate early genes, including proto-oncogenes FOS and JUN. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Product References

1) Duncan EA et al, J Biol Chem. 2006; vol.281(18): pp.12521-5. (General)
2) Soloaga A et al, EMBO J. 2003; vol.22(11) : pp.2788-97. (General)
3) Wiggin GR et al, Mol Cell Biol. 2002; vol.22(8): pp.2871-81. (General)

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