anti-Cyclin D3, pAb

CHF 322.00
In stock
YIF-LF-PA0053100 µlCHF 322.00
 
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Product Details
Synonyms CCND3; G1/S-specific Cyclin-D3
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application Western Blot (1:2,000)
Immunoprecipitation not tested.
Crossreactivity Human
Mouse
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Cyclin D3, ~34kDa, is a member of cyclin D family that promotes cell cycle progression to the DNA systhesis (S) phase. Cyclins complexed with cyclin-dependent kinases(CDKs) mediate phosphorylation of other proteins relevant to cell proliferation. D-type cyclins and their complexing CDKs phosphorylate the retinoblastoma gene product with influences transcription of growth-controlling genes. Cyclin D3 regulates cell proliferation during hematopoiesis, carcinogenesis, and may have function in the terminally differentiated cells. In recent studies, there is reports that cyclin D3 involves in multiple myeloma and malignant precursor T cells. Essential for the control of the cell cycle at the G1/S (start) transition. Potentiates the transcriptional activity of ATF5.
Product References
1) Watson DS et al, Oncology. 1999; vol.56(1): pp.66-72. (General)
2) Weng AP, Aster JC. Cancer Cell. 2003; vol.4(6): pp.451-61. (General)
3) Hideshima T et al, Blood. 2004; vol.104(3): pp.607-18. (General)
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