anti-Cyclin D3, pAb

Specifications / Handling

More Information
Product Details
Synonyms	CCND3; G1/S-specific Cyclin-D3
Product Type	Polyclonal Antibody
Properties
Immunogen/Antigen	Synthetic peptide.
Application	Western Blot (1:2,000) Immunoprecipitation not tested.
Crossreactivity	Human Mouse
Purity Detail	Protein A purified.
Formulation	Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
Declaration	Manufactured by AbFrontier
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Description

Cyclin D3, ~34kDa, is a member of cyclin D family that promotes cell cycle progression to the DNA systhesis (S) phase. Cyclins complexed with cyclin-dependent kinases(CDKs) mediate phosphorylation of other proteins relevant to cell proliferation. D-type cyclins and their complexing CDKs phosphorylate the retinoblastoma gene product with influences transcription of growth-controlling genes. Cyclin D3 regulates cell proliferation during hematopoiesis, carcinogenesis, and may have function in the terminally differentiated cells. In recent studies, there is reports that cyclin D3 involves in multiple myeloma and malignant precursor T cells. Essential for the control of the cell cycle at the G1/S (start) transition. Potentiates the transcriptional activity of ATF5.

Product References

1) Watson DS et al, Oncology. 1999; vol.56(1): pp.66-72. (General)
2) Weng AP, Aster JC. Cancer Cell. 2003; vol.4(6): pp.451-61. (General)
3) Hideshima T et al, Blood. 2004; vol.104(3): pp.607-18. (General)

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