anti-Glutathione Reductase, pAb

CHF 322.00
In stock
YIF-LF-PA0056100 µlCHF 322.00
More Information
Product Details
Synonyms GR; GSR; GLUR; GRase; EC=1.8.1.7; Glutathione Reductase, Mitochondrial
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application

Western Blot (1:2,000)
IHC-P
Immunoprecipitation not tested.

Crossreactivity Human
Mouse
Rat
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG) (1): GSSG + NADPH + H+ ⇔ 2GSH + NADP+ In most eukaryotic cells, GR maintains the ratio of [GSH]/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis (2). Maintains high levels of reduced glutathione in the cytosol.

Product References

1) Carlberg, I. and Mannervik, B. (1985) J. Biol. Chem. 261: 1629-1635. (General)
2) Picaud, T. and Desbois, A. (2002) J. Biol. Chem. 277: 31715-31721. (General)

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