anti-STAT2, pAb

CHF 322.00
In stock
YIF-LF-PA0065100 µlCHF 322.00
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Product Details
Synonyms p113; STAT2; Signal Transducer and Activator of Transcription 2
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

STAT2 (Signal transducer and activator of transcription 2), 113kDa, is a member of the STAT family of cytoplasmic transcription factors. STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction. STAT2 is a transcription factor critical to the signal transduction pathway of type I interferons (e.g. IFNα). STAT2 resides primarily in the cytoplasm and is tyrosine-phosphorylated after IFNα binds to cell surface receptors. In response to tyrosine phosphorylation STAT2 rapidly localizes to the nucleus and acquires the ability to bind specific DNA targets in association with two other proteins, STAT1 and IFN regulatory factor-9 (IRF-9). STAT2 is phosphorylated at Y689 by receptor-associated Janus kinasses (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription. Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-α and IFN-β). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Product References

1) Brierley MM, et al, J Interferon Cytokine Res. 2005; vol.25(12): pp.733-44. (General)
2)Brierley MM, Fish EN. J Biol Chem. 2005; vol.280(13): pp.13029-36. (General)
3)Banninger G, Reich NC. J Biol Chem. 2004; vol.279(38): pp.39199-206. (General)
4)Ihle JN. Curr Opin Cell Biol. 2001; vol.13(2): pp.211-7. (General)

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