anti-Phospho-Stat3 (Y705), pAb

CHF 315.00
In stock
YIF-LF-PA0071100 µlCHF 315.00
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Product Details
Synonyms APRF; STAT3; Acute-phase response Factor; Signal Transducer and Activator of Transcription 3
Product Type Polyclonal Antibody
Immunogen/Antigen Synthetic peptide.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Signal transducer and activator of transcription (STAT), named after their dual role, are latent cytoplasmic transcription factors that mediate various biological responses. The activation of STAT proteins is largely mediated by phosphorylation of C-terminal transactivation domain through Janus kinases (JAKs) and mitogen-activated protein kinases (MAPKs), which allows the activated STATs to dimerize and to translocate into the nucleus. By modulating target gene expression, STAT proteins play an important role in mediating a broad range of biological processes such as cell proliferation, survival, apoptosis, and differentiation. Seven mammalian members of the STAT family are known (STAT1, 2, 3, 4, 5a, 5b, and 6) and they all share common features and structure. STAT3 is activated by growth factors and oncogenic kinases where it mediates transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis. Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Product References

1) Aggarwal BB, et al, Ann N Y Acad Sci. 2006; vol.1091: p.151-69. (General)
2) Gao SP, Bromberg JF. Sci STKE. 2006; vol.2006(343): pe30. (General)
3) Inghirami G, et al, Cell Cycle. 2005; vol.4(9): p.1131-3. (General)
4) Jing N, Tweardy DJ. Anticancer Drugs. 2005; vol.16(6): p.601-7. (General)

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