anti-PKC ν (Protein Kinase C ν), pAb

CHF 315.00
In stock
YIF-LF-PA0073100 µlCHF 315.00
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Product Details
Synonyms EPK2; PRKD3; nPKC-ν; EC=; Protein Kinase EPK2; Protein Kinase C ν Type; Serine/Threonine-Protein Kinase D3
Product Type Polyclonal Antibody
Immunogen/Antigen Synthetic peptide.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Affinity purification.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Rabbit IgG

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
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Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Protein kinase C (PKC) is a family of serine-threonine kinases that regulate a broad spectrum of cellular functions. The family is composed of nine genes that express structurally related phospholipid-dependent kinases with distinct means of regulation and tissue distribution. Based on their structures and sensitivities to Ca2+ and diacylglycerol (DAG), they have been classified into conventional PKCs (α, β, and γ), novel PKCs (δ, ε, η, and θ), and atypical PKCs (ζ and λ/ι). A novel serine-threonine kinase of the protein kinase C (PKC) family has been described and designated as PKCν (PKC ν) which has two putative diacylglycerol binding C1 domains. PKCν is abundantly expressed in human β-cells, and it is a downstream effector for BCR (B-cell antigen receptor)-mediated DAG production. The closest homologues of PKCν are PKD1/PKCμ and PKD2, and together these three kinases form a distinct protein kinase subfamily. They share a predicted tertiary structure that includes two C1 domains contained in their amino-terminal halves, a single central pH domain, and closely homologous kinase domains in their COOH-terminal halves. Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.

Product References

1) Matthews S.A. et al., (2003) J Biol Chem. 278:9086-9091. (General)
2) Nakashima, S., (2002) J Biochem (Tokyo). 132:669-675. (General)
3) Saito N. and Shirai Y., (2002) J Biochem (Tokyo). 132:683-687. (General)
4) Hayashi, A. et al., (1999) Biochim Biophys Acta. 1450:99-106. (General)

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