anti-PKC ν (Protein Kinase C ν), pAb

CHF 322.00
In stock
YIF-LF-PA0073100 µlCHF 322.00
 
More Information
Product Details
Synonyms EPK2; PRKD3; nPKC-ν; EC=2.7.11.13; Protein Kinase EPK2; Protein Kinase C ν Type; Serine/Threonine-Protein Kinase D3
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application Western Blot (1:2,000)
Crossreactivity Human
Mouse
Purity Detail Affinity purification.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Protein kinase C (PKC) is a family of serine-threonine kinases that regulate a broad spectrum of cellular functions. The family is composed of nine genes that express structurally related phospholipid-dependent kinases with distinct means of regulation and tissue distribution. Based on their structures and sensitivities to Ca2+ and diacylglycerol (DAG), they have been classified into conventional PKCs (α, β, and γ), novel PKCs (δ, ε, η, and θ), and atypical PKCs (ζ and λ/ι). A novel serine-threonine kinase of the protein kinase C (PKC) family has been described and designated as PKCν (PKC ν) which has two putative diacylglycerol binding C1 domains. PKCν is abundantly expressed in human β-cells, and it is a downstream effector for BCR (B-cell antigen receptor)-mediated DAG production. The closest homologues of PKCν are PKD1/PKCμ and PKD2, and together these three kinases form a distinct protein kinase subfamily. They share a predicted tertiary structure that includes two C1 domains contained in their amino-terminal halves, a single central pH domain, and closely homologous kinase domains in their COOH-terminal halves. Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.
Product References
1) Matthews S.A. et al., (2003) J Biol Chem. 278:9086-9091. (General)
2) Nakashima, S., (2002) J Biochem (Tokyo). 132:669-675. (General)
3) Saito N. and Shirai Y., (2002) J Biochem (Tokyo). 132:683-687. (General)
4) Hayashi, A. et al., (1999) Biochim Biophys Acta. 1450:99-106. (General)
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