anti-Diazepam Binding Inhibitor, pAb

CHF 315.00
In stock
YIF-LF-PA0079100 µlCHF 315.00
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Product Details
Synonyms EP; DBI; ACBP; Endozepine; Acyl-CoA-binding Protein; Diazepam-binding Inhibitor
Product Type Polyclonal Antibody
Immunogen/Antigen Recombinant human GST-fusion protein purified from E. coli.

Western Blot (1:1,000)
Immunoprecipitation (1 μl)

Crossreactivity Human
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Rabbit IgG

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
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Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Diazepam Binding Inhibitor (DBI) is a highly conserved 10 kDa polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central and peripheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer disease. Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Product References

1) Shoyab, M. et al (1986) J. Biol. Chem. 261: 11968-11973. (General)
2) Gray, P.W. et al (1986) Proc. Nat. Acad. Sci. 83:7547-7551. (General)
3) Ohkuma, S. et al (2001) Life Science 68: 1215-1222. (General)

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