anti-p38 MAPK (Phospho-Thr180/Tyr182), pAb

CHF 322.00
In stock
YIF-LF-PA0089100 µlCHF 322.00
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Product Details
Synonyms Phospho-CSBP; Phospho-MAPK14; Phospho-SAPK2a; Phospho-MAPK 14; EC=2.7.11.24; Phospho-MAP Kinase 14; Phospho-MAP Kinase MXI2; Phospho-MAP Kinase p38 α; Phospho-CSAID-binding Protein
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic phospholyrated peptide (KLH coupled) corresponding to residues around Thr180/Tyr182 of human p38 MAP kinase.
Application

Western Blot (1:5,000)

Crossreactivity Human
Mouse
Rat
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation and other signals. p38 MAPK is relatively inactive in the non-phosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor-α, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 and –6 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation. Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Product References

1) Rouse, J. et al. (1994) Cell, 78: 1027-1037. (General)
2) Herlaar, E. and Brown, Z. (1999) Mol. Med. Today, 5(10): 439-447. (General)
3) Martin-Blanco, E. (2000) BioEssays, 22(7): 637-645. (General)
4) Olson, J.M. and Hallahan, A.R. (2004) Trends Mol. Med. 10(3): 125-129. (General)

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