anti-Peroxiredoxin 2, pAb

CHF 322.00
In stock
YIF-LF-PA0091100 µlCHF 322.00
 
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Product Details
Synonyms Prdx2; Prdx2 Protein
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant mouse Prx2 protein purified from E. coli.
Application Western Blot (1:2,000)
Crossreactivity Human
Mouse
Rat
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx 6 belonging to 1- Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxindependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 – 30 kilodalton in molecular size and vary in subcellular localization: Prx 1, 2, and 4 in cytosol, Prx 3 in mitochondria, Prx 4 in ER and secretion, Prx 5 showing complicated distribution including peroxisome, mitochondria and cytosol. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-α by regulating the intracellular concentrations of H2O2.
Product References
1) Choi M.H. et al., (2005) Nature Letters. 435:347-353. (General)
2) Tolle A. et al., (2005) Free Radic Biol Med. 38:1401-1408. (General)
3) Wood Z.A. et al., (2003) Trends Biochem Sci. 28:32-40. (General)
4) Rhee S.G. et al., (2001) IUBMB Life. 52:35-41. (General)
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