anti-BMP4, pAb

CHF 322.00
In stock
YIF-LF-PA0093100 µlCHF 322.00
More Information
Product Details
Synonyms BMP4; BMP2B; BMP-4; BMP-2B; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 2B
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application

Western Blot (1:2,000)

Crossreactivity Human
Mouse
Purity Detail Protein A purified.
Concentration 1 mg/ml
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Bone morphogenetic protein 4, also known as BMP4, is a member of the bone morphogenetic protein family which is part of the transforming growth factor-β superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo. BMPs also regulate cell proliferation, differentiation, lineage determination, motility, and death. BMP4 is a potent bone-inducing morphogen, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. BMP4 is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. It also plays a role in the epithelial-mesenchymal interactions leading to tooth formation. Both BMP2 and BMP4 have been found in calcified atherosclerotic plaques and aortic valve diseases, which suggests their importance in cardiovascular diseases. Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.

Product References

1) Chang KH et al., (2007) Circulation. 116:1258-1266. (General)
2) Yanagita M, (2005) Cytokine Growth Factor Rev. 16(3):309-317. (General)
3) Canalis E et al., (2003) Endocr Rev. 2003 24(2):218-235. (General)

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