Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
anti-BMP4, pAb
Product Details | |
---|---|
Synonyms | BMP4; BMP2B; BMP-4; BMP-2B; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 2B |
Product Type | Polyclonal Antibody |
Properties | |
Immunogen/Antigen | Synthetic peptide. |
Application |
Western Blot (1:2,000) |
Crossreactivity |
Human Mouse |
Purity Detail | Protein A purified. |
Concentration | 1 mg/ml |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
![]() |
Bone morphogenetic protein 4, also known as BMP4, is a member of the bone morphogenetic protein family which is part of the transforming growth factor-β superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo. BMPs also regulate cell proliferation, differentiation, lineage determination, motility, and death. BMP4 is a potent bone-inducing morphogen, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. BMP4 is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. It also plays a role in the epithelial-mesenchymal interactions leading to tooth formation. Both BMP2 and BMP4 have been found in calcified atherosclerotic plaques and aortic valve diseases, which suggests their importance in cardiovascular diseases. Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.
1) Chang KH et al., (2007) Circulation. 116:1258-1266. (General)
2) Yanagita M, (2005) Cytokine Growth Factor Rev. 16(3):309-317. (General)
3) Canalis E et al., (2003) Endocr Rev. 2003 24(2):218-235. (General)