anti-NSE (γ Enolase), pAb

CHF 322.00
In stock
YIF-LF-PA0108100 µlCHF 322.00
More Information
Product Details
Synonyms NSE; ENO2; Enolase 2; EC=4.2.1.11; γ-Enolase; Neural Enolase; Neuron-specific Enolase; 2-Phospho-D-Glycerate Hydro-lyase
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant human His-γ-enolase purified from E. coli.
Application

Western Blot (1:2,000)
Immunoprecipitation not tested.

Crossreactivity Human
Mouse
Rat
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phospho-enolpyruvate. It comprises three distint subunits, α, β and γ. The γγ and αγ dimeric forms of enolase, referred to as neuron-specific enolase(NSE), are localized mainly in neurons and neuroectodermal tissue. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid(CSF) when neuronal membranes are injured. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.

Product References

1) Fletcher, L. et al. (1976) Biochim. Biophys. Acta. 452(1), 245-252. (General)
2) Lima, J.E. et al. (2004) J. Neurol. Sci. 217(1), 31-35. (General)
3) Suzuki, Y. et al. (1999) Neurology 53(8), 1761-1764. (General)

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