anti-Synaptotagmin VI, pAb

CHF 322.00
In stock
YIF-LF-PA0113100 µlCHF 322.00
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Product Details
Synonyms SYT6; SytVI; Synaptotagmin-6; Synaptotagmin VI
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant human His-SytVI protein purified from E. coli.
Application

Western Blot (1:2,000)
IHC-P
Immunoprecipitation not tested.

Crossreactivity Human
Mouse
Rat
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF

Synaptotagmins (Syts) are a large gene family of synaptic vesicle integral membrane proteins. Syt functions as regulators of both exocytosis/endocytosis and is involved in neurotransmitter secretion from small secretory vesicles. 13 isoforms of Syt have been identified (SytI-XIII). SynaptotagminVI is localized to the endoplasmic reticulum and/or Golgi-like perinuclear compartment. It may be important for trafficking and calcium signaling as it is specially expressed in non-neuronal tissues. Also SytVI is present in the acrosomal region of mammalian spermatozoa. The cytosolic domain of SytVI can abrogate exocytosis by competing with the endogenous protein for essential interactions with the fusion machinery involved in a acrosomal exocytosis. May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Product References

1) Michaut M, et al.(2001) Dev Biol. 235 (2);521-9. (General)
2) Mikoshiba K, et al.(1999) Chem Phys Lipids. 98(1-2);59-67. (General)
3) Butz S, et al.(1999) J Biol Chem. 274(26); 18290-6. (General)

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