anti-Transglutaminase 2, pAb

CHF 322.00
In stock
YIF-LF-PA0117100 µlCHF 322.00
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Product Details
Synonyms TGC; TGM2; TG(C); TGase H; TGase-2; TGase C; EC=2.3.2.13; Transglutaminase-2; Transglutaminase H; Transglutaminase C; Tissue transglutaminase; Protein-Glutamine γ-Glutamyltransferase 2
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant human protein purified from E. coli.
Application

Western Blot (1:2,000)
Immunoprecipitation (1 μl)

Crossreactivity Human
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Transglutaminase (TGase) catalyses the crosslink of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core and two C-terminal β-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer’s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Aβ peptide, β-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Product References

1) Griffin, M. et al. (2002) Biochem. J. 368, 377-396. (General)
2) Fesus, L. and Piacentini, M. (2002) Trends. Biochem. Sci. 27(10), 534-539. (General)
3) Kim, SY. et al. (2002) Neurochem. Int. 40, 85-103. (General)

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