anti-CDK5, pAb
| Product Details | |
|---|---|
| Synonyms | CDK5; CDKN5; EC=2.7.11.22; TPKII Catalytic Subunit; Cyclin-dependent Kinase 5; Cell Division Protein Kinase 5; Tau Protein Kinase II Catalytic Subunit; Serine/Threonine-Protein Kinase PSSALRE |
| Product Type | Polyclonal Antibody |
| Properties | |
| Immunogen/Antigen | Recombinant human His-CDK5 protein purified from Baculovirus expressed insect cells. |
| Application |
Western Blot (1:2,000) |
| Crossreactivity |
Human Mouse |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Cyclin-dependent kinase-5 (CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in the kidneys, testes, and ovaries. And Its activity has been detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity; however, Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits, called p35 and p39. These two activators regulate the spatial and temporal expression of active Cdk5, restricting its activity primarily to post-mitotic neurons. Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.
1) Shirley B. Shelton and Gail V.W. Johnson (2004) Journal of Neurlchemistry 88,1313-1326. (General)
2) Jonathan C Cruz and Li-Huei Tsai (2004) Current Poinion in Neurobiology 14:390-394. (General)
3) Deanna S. Smith, et al. (2001) Cell Growth & Differentiation 12,277-283. (General)
