anti-VDAC 1, pAb

CHF 322.00
In stock
YIF-LF-PA0155100 µlCHF 322.00
 
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Product Details
Synonyms VDAC; VDAC1; hVDAC1; VDAC-1; Porin 31HM; Porin 31HL; Plasmalemmal Porin; Outer Mitochondrial Membrane Protein Porin 1; Voltage-dependent Anion-selective Channel Protein 1
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthesis peptide (KLH coupled) corresponding to C-terminal residues of Human VDAC1.
Application Western Blot (1:2,000)
Crossreactivity Human
Mouse
Rat
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Voltage-dependent anion channel(VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC contitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity. Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Product References
1) Hinsch KD, et al.(2004) J. Biol. Chem. 279(15):15281-8. (General)
2) Liberatori S, et al.(2004) Proteomics, 4(5):1335-40. (General)
3) Alfons Lawen, et al.(2005) Int J Biochem Cell Biol. 37(2):277-82. (General)
4) Mark A. Baker, et al.(2004) J. Biol. Chem. 279(6):4811-4819. (General)
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