anti-Cyclin E1, pAb

CHF 315.00
In stock
YIF-LF-PA0168100 µlCHF 315.00
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Product Details
Synonyms CCNE; CCNE1; G1/S-specific Cyclin-E1
Product Type Polyclonal Antibody
Immunogen/Antigen Recombinant human His-Cyclin E1 protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Cyclins play a key role in the orderly progression of the cell division cycle through their timed expression and their ability to bind, activate and enhance substrate affinity of their associated cyclin-dependent protein kinases (CDKs). E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase. Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the cyclic/Cdk2 complexes initiate a cascade of events that leads to the expression of S-phase specific genes. Besides this specific function as a regulator of S-phase-entry, cyclin E plays a direct role in the initiation of DNA replication, the control of genomic stability, and the centrosome cycle. Essential for the control of the cell cycle at the G1/S (start) transition.

Product References

1) Moroy T, Geisen C. Int J Biochem Cell Biol. 2004; vol.36: p.1424-39. (General)
2) Honda R, et al, EMBO J. 2005; vol.24: p.452-63. (General)
Karp G. (2005). Cell and Molecular Biology: Concepts and Experiments, 4th ed, John Wiley and Sons, Hoboken, NJ. (General)

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