anti-Cyclin E1, pAb

CHF 322.00
In stock
YIF-LF-PA0168100 µlCHF 322.00
 
More Information
Product Details
Synonyms CCNE; CCNE1; G1/S-specific Cyclin-E1
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant human His-Cyclin E1 protein purified from E. coli.
Application Western Blot (1:2,000)
IHC-P
Crossreactivity Human
Mouse
Rat
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Cyclins play a key role in the orderly progression of the cell division cycle through their timed expression and their ability to bind, activate and enhance substrate affinity of their associated cyclin-dependent protein kinases (CDKs). E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase. Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the cyclic/Cdk2 complexes initiate a cascade of events that leads to the expression of S-phase specific genes. Besides this specific function as a regulator of S-phase-entry, cyclin E plays a direct role in the initiation of DNA replication, the control of genomic stability, and the centrosome cycle. Essential for the control of the cell cycle at the G1/S (start) transition.
Product References
1) Moroy T, Geisen C. Int J Biochem Cell Biol. 2004; vol.36: p.1424-39. (General)
2) Honda R, et al, EMBO J. 2005; vol.24: p.452-63. (General)
Karp G. (2005). Cell and Molecular Biology: Concepts and Experiments, 4th ed, John Wiley and Sons, Hoboken, NJ. (General)
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