anti-IRAK4, pAb

CHF 322.00
In stock
YIF-LF-PA0173100 µlCHF 322.00
More Information
Product Details
Synonyms IL-1 Receptor-associated Kinase 4
Product Type Polyclonal Antibody
Properties
Source/Host Rabbit
Immunogen/Antigen Synthetic peptide.
Application

Western Blot

Crossreactivity Human
Mouse
Rat
Purity Detail Affinity purification.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. All TIRs with known function are involved in host defense mechanisms, either by the recognition of pathogens or as receptors for proinflammatory cytokines. They play a crucial role in the switch from innate to adaptive immunity in mammals, and the signaling cascades initiated by these receptors are implicated in a number of human diseases. To date, four IRAK genes have been identified in the human genome, namely IRAK1, IRAK2, IRAK-M and IRAK4. Each distinct IRAK may have highly specific downstream target, and therefore, contribute to the specific activation of cellular response upon distinct TLR ligand challenge, such as signaling pathways leading to cellular apoptosis (IRAK2), NF-κB activation and inflammatory cytokine expression (IRAK4 and 2), Stat3 activation and IL-10 expression (IRAK1), and inhibition of NF-κB activation (IRAK-M).

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