anti-CKII β (Casein Kinase 2 β), pAb

CHF 322.00
In stock
YIF-LF-PA0193100 µlCHF 322.00
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Product Details
Synonyms CK2N; CSNK2B; Phosvitin; CK II β; Protein G5a; Casein Kinase II Subunit β
Product Type Polyclonal Antibody
Immunogen/Antigen Recombinant human His-CKII β protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Affinity purification.
Concentration 1 mg/ml
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

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Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

The casein kinase I (CKI) family of serine/threonine protein kinases is highly conserved from yeast to humans. The CKI family is involved in many diverse and important cellular functions, such as regulation of membrane transport, cell division, DNA repair, circadian rhythms, and nuclear localization. The name of the enzyme family was originated from the convenience of casein as a substrate since the earliest days of research on protein phosphorylation. Casein kinase 2 (CK2) is a ubiquitous, highly conserved, essential serine/threonine kinase which has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. CK2 is a tetramer of two α subunits and two β subunits. The α subunits have the catalytic kinase domain. Loss of the α‘ catalytic subunit produces male infertility, and loss of the single β regulatory subunit is early embryonic lethal. CK2 appears to be upregulated in most cancers and the promotion of tumorigenesis by the overexpression of CK2 has been reported in transgenic mice. Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the α subunit.

Product References

1) Price M.A., (2006) Genes Dev. 20:399-410. (General)
2) Seldin DC et al., (2005) Mol Cell Biochem. 274(1-2):63-67. (General)
3) Tobin A.B., (2002) Trends Pharmacol Sci. 23:337-343. (General)
4) Gross S.D. and Anderson R.A., (1998) Cell Signal. 10:699-711. (General)

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