anti-pan-Synuclein, pAb

CHF 322.00
In stock
YIF-LF-PA0194100 µlCHF 322.00
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Product Details
Synonyms SNCB; β-Synuclein
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Recombinant human His-β-Synuclein protein purified from E. coli.
Application

Western Blot (1:2,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Affinity purification.
Concentration 1 mg/ml
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF

Synuclein is a small, soluble protein primarily expressed in neural tissue. The synuclein family includes three known proteins: α-synuclein, β-synuclein, and γ-synuclein. α-Synuclein is a very conserved, small acidic protein (140 residues) with a molecular weight of approximately 19 kDa that accounts for about 1% of total protein in neurons. It is concentrated primarily in presynaptic axon terminals and plays a central role in initiating Parkinson’s disease. It is the principal constituent of Lewy bodies which are formed by protein aggregation and inclusion body formation. α-Synuclein lacks secondary or tertiary structure, so it belongs to the family of natively unfolded proteins, many of which act as chaperones. Much of this α-synuclein has been post-translationally modified to increase the rate of oligomerization. Mutant forms of α-Synuclein are associated with autosomal dominant Parkinson’s disease. The mutations increase the aggregation rate of the resultant α-synuclein β-Synuclein is found primarily in brain tissue and is seen mainly in presynaptic terminals. It is predominantly expressed in the neocortex, hippocampus, striatum, thalamus, and cerebellum. β-Synuclein may protect the central nervous system from the neurotoxic effects of α-synuclein by inhibiting aggregation of α-synuclein which occurs in neurodegenerative diseases such as Parkinson's disease. γ-Synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. γ-Synuclein expression in breast tumors is a marker for tumor progression. Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Product References

1) Irvine GB et al., (2008) Mol Med. (General)
2) Wakabayashi K et al., (2007) Neuropathology 27(5):494-506. (General)
3) Beyer K., Acta Neuropathol 112(3):237-251. (General)
4) Bruening W et al., (2000) Cancer 88(9):2154-2163. (General)

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