anti-pan-Synuclein, pAb

CHF 315.00
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YIF-LF-PA0194100 µlCHF 315.00
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Product Details
Synonyms SNCB; β-Synuclein
Product Type Polyclonal Antibody
Immunogen/Antigen Recombinant human His-β-Synuclein protein purified from E. coli.

Western Blot (1:2,000)

Crossreactivity Human
Purity Detail Affinity purification.
Concentration 1 mg/ml
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Rabbit IgG

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Synuclein is a small, soluble protein primarily expressed in neural tissue. The synuclein family includes three known proteins: α-synuclein, β-synuclein, and γ-synuclein. α-Synuclein is a very conserved, small acidic protein (140 residues) with a molecular weight of approximately 19 kDa that accounts for about 1% of total protein in neurons. It is concentrated primarily in presynaptic axon terminals and plays a central role in initiating Parkinson’s disease. It is the principal constituent of Lewy bodies which are formed by protein aggregation and inclusion body formation. α-Synuclein lacks secondary or tertiary structure, so it belongs to the family of natively unfolded proteins, many of which act as chaperones. Much of this α-synuclein has been post-translationally modified to increase the rate of oligomerization. Mutant forms of α-Synuclein are associated with autosomal dominant Parkinson’s disease. The mutations increase the aggregation rate of the resultant α-synuclein β-Synuclein is found primarily in brain tissue and is seen mainly in presynaptic terminals. It is predominantly expressed in the neocortex, hippocampus, striatum, thalamus, and cerebellum. β-Synuclein may protect the central nervous system from the neurotoxic effects of α-synuclein by inhibiting aggregation of α-synuclein which occurs in neurodegenerative diseases such as Parkinson's disease. γ-Synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. γ-Synuclein expression in breast tumors is a marker for tumor progression. Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Product References

1) Irvine GB et al., (2008) Mol Med. (General)
2) Wakabayashi K et al., (2007) Neuropathology 27(5):494-506. (General)
3) Beyer K., Acta Neuropathol 112(3):237-251. (General)
4) Bruening W et al., (2000) Cancer 88(9):2154-2163. (General)

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