anti-γ-Synuclein, pAb
| Product Details | |
|---|---|
| Synonyms | SR; SNCG; BCSG1; Persyn; Synoretin; γ-Synuclein; Breast Cancer-specific Gene 1 Protein |
| Product Type | Polyclonal Antibody |
| Properties | |
| Immunogen/Antigen | Recombinant human His-γ Synuclein protein purified from E. coli. |
| Application |
Western Blot (1:2,000) |
| Crossreactivity | Human |
| Purity Detail | Affinity purification. |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Synuclein is a small, soluble protein primarily expressed in neural tissue. The synuclein family includes three known proteins: α-synuclein, β-synuclein, and γ-synuclein. γ-Synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. γ-Synuclein expression in breast tumors is a marker for tumor progression. Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
1) Irvine GB et al., (2008) Mol Med. (General)
2) Wakabayashi K et al., (2007) Neuropathology 27(5):494-506. (General)
3) Beyer K., Acta Neuropathol 112(3):237-251. (General)
4) Bruening W et al., (2000) Cancer 88(9):2154-2163. (General)
