anti-Cathepsin D, pAb

CHF 315.00
In stock
YIF-LF-PA0204100 µlCHF 315.00
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Product Details
Synonyms CTSD; CPSD; EC=
Product Type Polyclonal Antibody
Immunogen/Antigen Recombinant human His-Cathepsin D protein purified from E. coli.

Western Blot (1:5,000)

Crossreactivity Human
Purity Detail Affinity purification.
Concentration 1 mg/ml
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Rabbit IgG

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Cathepsin D (CatD) is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins apoptosis and autophagy. Human CatD is synthesized on the endoplasmic reticulum as a pre-pro-enzyme. Preprocathepsin D (412aa) is cleaved and glycosylated to form an inactive procathepsin D (392aa) and then further cleaved to generate an active intermediate (348aa) single-chain molecule. The active intermediate is further processed into mature two chain form of cathepsin D, this processing step is carried out by cathepsin B or L. The two-chain form consists of an amino terminal light chain (14 kDa) and a carboxyl-terminal heavy chain (34 kDa). Additionally, several more amino acids are removed from the carboxyl terminus of the 34 kDa heavy chain. Procathepsin D (pCD), secreted from cancer cells, acts as a mitogen on both cancer and stromal cells and stimulates their proinvasive and pro-metastatic properties. Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Product References

1) Zaidi N et al., (2008) Biochem Biophys Res Commun 7;376(1):5-9. (General)
2) Liaudet-Coopman, E. et al., (2006) Cancer Lett 237, 167-179. (General)

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