anti-Connexin 43, pAb

CHF 322.00
In stock
YIF-LF-PA0205100 µlCHF 322.00
More Information
Product Details
Synonyms GJAL; Cx43; GJA1; Connexin-43; Gap Junction α-1 Protein; Gap Junction 43 kDa Heart Protein
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Synthetic peptide.
Application

Western Blot (1:1,000~5,000)

Crossreactivity Human
Mouse
Rat
Purity Detail Protein A purified.
Concentration 1 mg/ml
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Connexin 43 (Cx43) is a widely expressed gap junction protein that mediates communication between many cell types. Gap junctions are implicated in tissue homeostasis and control of cell proliferation and differentiation. Connexin 43 is predominantly localized at the sarcolemma, where six connexins assemble into a so-called connexon or hemichannel. Clusters of these channels assemble to make gap junctions. Cx43 is a target protein of several kinases, among them PKA, PKC, PKG, MAPK, and casein kinase, but also for protein phosphatases. The phosphorylation of Cx43 at Ser368 by PKC induces a closure of Hemichannels. Src can phosphorylate Cx43 to alter gap junction communication. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Product References

1) Pahujaa M et al., (2007) Exp Cell Res 313(20):4083-90. (General)
2) Schulz R et al., (2007) Heart Fail Rev 12(3-4):261-6. (General)
3) Solan JL and Lampe PD, (2005) Biochim Biophys Acta 10;1711(2):154-63. (General)

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