anti-Lactoferrin, pAb

CHF 322.00
In stock
YIF-LF-PA0220100 µlCHF 322.00
 
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Product Details
Synonyms LTF; GIG12; EC=3.4.21.
Product Type Polyclonal Antibody
Properties
Immunogen/Antigen Human Lactoferrin purified from first breast milk.
Application Western Blot (1:2,000)
Crossreactivity Human
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Other Product Data Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS No
Product Specification Sheet
Datasheet Download PDF
Lactoferrin (Lf), one of transferrin family, is found in external fluids, including milk and mucosal secretions, and prominent components of the secondary granules of neutrophils. Lf consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). Lf plays a central role in iron metabolism and host defense system against microbial infection. Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for κ-receptors than for mu-receptors. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.
Product References
1) Farnaud, S. and Evans, R.W. (2003) Mol. Immunol. 40, 395-405. (General)
2) Baker, H.M. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 3579-3583. (General)
3) Appelmelk, B.J. et al. (1994) Infect. Immun. 62, 2628-2632. (General)
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