anti-Transglutaminase 2 (TG2), pAb

CHF 315.00
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YIF-LF-PA0223100 µlCHF 315.00
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Product Details
Synonyms TGC; TGM2; TG(C); TGase H; TGase-2; TGase C; EC=; Transglutaminase C; Transglutaminase H; Transglutaminase-2; Tissue Transglutaminase; Protein-Glutamine γ-Glutamyltransferase 2
Product Type Polyclonal Antibody
Immunogen/Antigen Recombinant human protein purified from E. coli.

Western Blot (1:2,000~5,000)

Crossreactivity Human
Purity Detail Protein A purified.
Formulation Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Isotype Negative Control

Rabbit IgG

Other Product Data

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Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by AbFrontier
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
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Product Specification Sheet
Datasheet Download PDF

Transglutaminase (TGase) catalyses the crosslink of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core and two C-terminal β-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer’s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Aβ peptide, β-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Product References

1) Griffin, M. et al. (2002) Biochem. J. 368, 377-396. (General)
2) Fesus, L. and Piacentini, M. (2002) Trends. Biochem. Sci. 27(10), 534-539. (General)
3) Kim, SY. et al. (2002) Neurochem. Int. 40, 85-103. (General)

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