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anti-Transglutaminase 2 (TG2), pAb
Product Details | |
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Synonyms | TGC; TGM2; TG(C); TGase H; TGase-2; TGase C; EC=2.3.2.13; Transglutaminase C; Transglutaminase H; Transglutaminase-2; Tissue Transglutaminase; Protein-Glutamine γ-Glutamyltransferase 2 |
Product Type | Polyclonal Antibody |
Properties | |
Immunogen/Antigen | Recombinant human protein purified from E. coli. |
Application |
Western Blot (1:2,000~5,000) |
Crossreactivity | Human |
Purity Detail | Protein A purified. |
Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
Declaration | Manufactured by AbFrontier |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Transglutaminase (TGase) catalyses the crosslink of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core and two C-terminal β-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer’s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Aβ peptide, β-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
1) Griffin, M. et al. (2002) Biochem. J. 368, 377-396. (General)
2) Fesus, L. and Piacentini, M. (2002) Trends. Biochem. Sci. 27(10), 534-539. (General)
3) Kim, SY. et al. (2002) Neurochem. Int. 40, 85-103. (General)