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AdipoGen Life Sciences
PEDF (human) (rec.)
265
CHF
CHF 265.00
In stock
AG-40B-0077-C01010 µgCHF 265.00
AG-40B-0077-30103 x 10 µgCHF 530.00
| Product Details | |
|---|---|
| Synonyms | Pigment Epithelium-derived Factor; Cell Proliferation-inducing Gene 35 Protein; EPC-1; Serpin F1 |
| Product Type | Protein |
| Properties | |
| Source/Host | CHO cells |
| Sequence | Human PEDF (aa 20-418) is fused at the C-terminus of to a FLAG®-tag. |
| Crossreactivity | Human |
| MW | ~47kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.1EU/μg purified protein (LAL test; Lonza). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile distilled water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data | UniProt link P36955: PEDF (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Pigment epithelium-derived factor (PEDF) is a 47 kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and foetal tissues, including brain, spinal cord, plasma, bone, prostate, pancreas, heart and lung. PEDF acts as an angiogenesis inhibitor with neurotrophic, immunomodulation and antitumor properties. It functions as anti-angiogenic agent by counterbalancing the proangiogenic effect of VEGF. PEDF is one of the most abundant proteins released by adipocytes and induces insulin resistance in adipocytes and human skeletal muscle cells. Recently, it has been reported that PEDF is sufficient to maintain the self-renewal of pluripotent human embryonic stem cells.
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