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Innovative Research Reagents for Inflammation & Immune Responses
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Latest Product Highlights ArchiveVSTM5 - A Novel Immune Checkpoint regulating Treg Generation
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News & Press ReleasesAbcalis and AdipoGen Life Sciences Partner on Distributing Animal-free Recombinant Monoclonal and Multiclonal Antibodies on the Life Science Research Market Periostin Deficiency Reduces PD-1+ Tumor-associated Macrophages A recent study published in Cell Reports describes the mechanism of action of Periostin in CRC. Periostin deficiency in tumor microenvironment (TME) significantly decreases the infiltration of PD-1+ TAMs (pro-tumoral) in colorectal cancer tissues of mice leading to suppression of tumor growth. Inhibition of both periostin and PD-1 significantly suppresses CRC progression and this approach could improve immune therapy efficacy in CRC in humans. |
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