Innaxon - Innate Immunity to Life

The Experts for TLR agonists and antagonists

Innaxon develops and manufactures defined “Immunoceuticals” of the highest activity and purity for pre-clinical research and development applications for vaccine adjuvants and immuno-therapy. Our unique biological and synthetic Toll-like Receptor (TLR) ligands are well-characterized and effective biological response modifiers of inappropriate or disproportionate immune responses. AdipoGen Life Sciences provides Innaxon Products worldwide. For product inquiries contact: info@adipogen.com For the corporate website see: www.innaxon.co.uk

The TLR4/LPS Experts – Highest Quality

• TLRpure™: Qualified Purity & Activity
• High potency TLR4-specific ligands
• Ultrapure (no detectable protein, RNA & DNA)
• Tested on TLR4 KO murine macrophages
• Standardized aqueous sterile solutions
• Ready-to-use Lipid A and MPLA solutions
• No purification or hazardous solubilization
• BULK available for in vivo studies
• Excellent lot-to-lot reproducibility
• Broadest LPS chemotype and serotypeselection
• Unique TLR4 Explorer Sets™
• More than 40 years of experience in LPS purification & characterisation

The ODN Experts – Competitive Prices

• Endotoxin-free and sterile
• Potent TLR9 ligands
• Tested on TLR9 KO murine macrophages
• BULK available for in vivo studies
• ddWater Endotoxin-free (sterile) included
• Unique TLR9 Explorer Sets™
• Inhibitory ODNs (iODNs) available
• Negative ODN Controls available

IAXO Compounds – Unique!

• Novel small molecule CD14/TLR4 antagonists
• Potent pre-clinical in vivo activity
• Inactive control compounds available

Product Overview of all Innaxon Products

Lipopolysaccharides (LPS)

PID	Product Name	Size
S-Form LPS
IAX-100-009	LPS (Universal) from S. abortus equi (S-form) TLRpure™ Sterile Solution THE STANDARD	500 µg 1 mg 2 mg
IAX-100-009B	LPS (Universal) from S. abortus equi (S-form) Biotin TLRpure™ Sterile Solution THE STANDARD	200 µg 500 µg 1 mg
IAX-100-006	LPS from E. coli O8:K27 (S-form) TLRpure™ Sterile Solution	500 µg 1 mg 2 mg
IAX-100-012	LPS from E. coli O111:B4 (S-form) TLRpure™ Sterile Solution	500 µg 1 mg 2 mg
IAX-100-013	LPS from E. coli O55:B5 (S-form) TLRpure™ Sterile Solution	500 µg 1 mg 2 mg
IAX-100-019	LPS from S. enteritidis (S-form) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-020	LPS from S. minnesota (S-form) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-011	LPS from S. typhimurium (S-form) TLRpure™ Sterile Solution	500 µg 1 mg
R-Form LPS
IAX-100-007	LPS from E. coli R515 (Re) TLRpure™ Sterile Solution THE STANDARD	500 µg 1 mg
IAX-100-008	LPS from S. minnesota R595 (Re) TLRpure™ Sterile Solution THE STANDARD	500 µg 1 mg 2 mg
IAX-100-010	LPS from E. coli EH100 (Ra) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-016	LPS from S. minnesota R60 (Ra) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-015	LPS from S. minnesota R345 (Rb) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-017	LPS from S. minnesota R5 (Rc) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-014	LPS from E. coli J5 (Rc) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-018	LPS from S. minnesota R7 (Rd1) TLRpure™ Sterile Solution	500 µg 1 mg
IAX-100-021	LPS from S. minnesota R3 (Rd2) TLRpure™ Sterile Solution	500 µg 1 mg
Lipid A and MLPA
IAX-100-004	Lipid A from E. coli R515 (Re) TLRpure™ Sterile Solution	250 µg 500 µg 1 mg
IAX-100-001	Lipid A from S. minnesota R595 (Re) TLRpure™ Sterile Solution	250 µg 500 µg 1 mg
IAX-100-002	MPLA from S. minnesota R595 (Re) TLRpure™ Sterile Solution	250 µg 500 µg 1 mg
IAX-100-003	MPLA from E. coli R515 (Re) TLRpure™ Sterile Solution	250 µg 500 µg 1 mg

Endotoxin-free Oligonucleotides

PID	Product Name	Size
ODNs
IAX-200-001	ODN 1668 (Type B) Endotoxin-free (sterile) THE STANDARD	100 µg 1 mg 3 x 1 mg
IAX-200-002	ODN 1826 (Type B) Endotoxin-free (sterile) THE STANDARD	100 µg 1 mg 3 x 1 mg
IAX-200-005	ODN 2216 (Type A) Endotoxin-free (sterile) THE STANDARD	100 µg 1 mg 3 x 1 mg
IAX-200-003	ODN 1585 (Type A) Endotoxin-free (sterile)	100 µg 1 mg 3 x 1 mg
IAX-200-004	ODN M362 (Type C) Endotoxin-free (sterile)	100 µg 1 mg
IAX-200-006	ODN 2006 (Type B) Endotoxin-free (sterile)	100 µg 1 mg 3 x 1 mg
IAX-200-007	ODN 2395 (Type C) Endotoxin-free (sterile)	100 µg 1 mg 3 x 1 mg
iODNs
IAX-200-050	iODN (inhibitory ODN) 2088 Endotoxin-free (sterile)	100 µg 1 mg 3 x 1 mg
IAX-200-051	iODN (inhibitory ODN) (ttaggg)4 Endotoxin-free (sterile)	100 µg 1 mg
IAX-200-052	G-type iODN (inhibitory ODN) Endotoxin-free (sterile)	100 µg 1 mg
IAX-200-053	Mini-iODN (inhibitory ODN) Endotoxin-free (sterile)	100 µg
IAX-200-054	Mega-iODN (inhibitory ODN) Endotoxin-free (sterile)	100 µg
IAX-200-055	Duo-iODN (inhibitory ODN) Endotoxin-free (sterile)	100 µg 1 mg
IAX-200-056	NEW TLR7-iODN (inhibitory ODN) Endotoxin-free (sterile)	100 µg 1 mg
Controls
IAX-200-200	ODN 1720 (Control for ODN 1668) Endotoxin-free (sterile)	100 µg
IAX-200-201	ODN 1982 (Control for ODN 1826) Endotoxin-free (sterile)	100 µg
IAX-200-202	Neutral-ODN (Control for iODNs) Endotoxin-free (sterile)	100 µg 1 mg
IAX-200-203	ODN 2118 (Control for ODN 1585) Endotoxin-free (sterile)	100 µg
IAX-200-204	ODN M383 (Control for ODN M362) Endotoxin-free (sterile)	100 µg
IAX-200-205	ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile)	100 µg
IAX-200-206	ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile)	100 µg
IAX-200-208	NEW CTRL2-ODN (Control for iODN and CpG-ODNs) Endotoxin-free (sterile)	100 µg 1 mg

Endotoxin-free Immunoceuticals

PID	Product Name	Size
IAX-200-021	Poly(I:C) Endotoxin-free (sterile)	2 mg 5 mg 3 x 5 mg
IAX-200-101	Trehalose 6,6’-dimycolate (TDM) [Cord Factor] Endotoxin-free (sterile)	100 µg

IAXO Compounds - TLR4 Antagonists

PID	Product Name	Size
IAX-600-001	IAXO-101 (CD14/TLR4 Antagonist) (synthetic)	1 mg
IAX-600-002	IAXO-102 (CD14/TLR4 Antagonist) (synthetic)	1 mg
IAX-600-003	IAXO-103 (CD14/TLR4 Antagonist) (synthetic)	1 mg

TLR4 Monoclonal Antibodies

PID	Product Name	Size
IAX-400-002	anti-TLR4 (human), mAb (blocking) (22C5)	100 µg
IAX-400-003	anti-TLR4 (human), mAb (2E11)	100 µg
IAX-400-004	anti-TLR4 (human), mAb (28H7)	100 µg

Accessories

PID	Product Name	Size
IAX-900-001	PBS Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml 3 x 100 ml 500 ml
IAX-900-001DC	PBS Endotoxin-free (sterile) [For Nano-formulated Drug Analysis]	10 ml
IAX-900-002	ddWater Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml 3 x 100 ml 500 ml
IAX-900-002DC	ddWater Endotoxin-free (sterile) [For Nano-formulated Drug Analysis]	10 ml
IAX-900-003	Physiological Saline [Sodium Chloride 0.9%] Sterile Solution	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml 3 x 100 ml 500 ml
IAX-900-003DC	Physiological Saline [Sodium Chloride 0.9%] Endotoxin-free (sterile) [For Nano-formulated Drug Analysis]	10 ml
IAX-900-004	PBS with EDTA Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-005	TRIS with EDTA [TE Buffer ] (100x) Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-006	EDTA (400mM) Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-007	HEPES Buffer (500mM) Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-008	DNA Loading Buffer with TRIS and EDTA (6x) (Blue)	1.5 ml 5 x 1.5 ml
IAX-900-009	HEPES Buffer (50mM) with NaCl [Sodium Chloride] (150mM) Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-010	NaCl [Sodium Chloride] (1.5M) Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-011	TRIS Buffer (1.5M) Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-012	TRIS Buffer (30mM) with NaCl [Sodium Chloride] (150mM) Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-013	PBS with Magnesium and Calcium Endotoxin-free (sterile)	1.5 ml 5 x 1.5 ml 10 ml 3 x 10 ml 100 ml
IAX-900-014	ddWater with 0.9% Benzyl Alcohol [Bacteriostatic Water] Endotoxin-free (sterile)	10 ml 3 x 10 ml
IAX-700-001	Argania Spinosa Kernel Oil (natural) (pure)	10 ml 3 x 10 ml 100 ml 3 x 100 ml

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Innaxon - Innate Immunity to Life

The Experts for TLR agonists and antagonists

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