MultimericLigands™ - Higher Activity - Lower Endotoxin

AdipoGen Life Sciences' Multimeric Proteins are high-activity constructs in which two trimeric TNFSF ligands are linked via the oligomeric collagen domain of ACRP30 [ACRP30headless] and therefore mimic the membrane-bound forms of the proteins.

The Largest Panel of Ultrapotent Multimeric Ligands™
Equivalent to MegaLigands!

Endogenous TNF superfamily ligands are either active as membrane-form (e.g. FasL, TRAIL, CD40L, OX40L) or are secreted and activated through oligomerization by the binding of proteoglycans at the surface of cells (e.g. APRIL). The oligomerization is triggered
• by fusing the TNF superfamily ligands to the collagen domain of the protein ACRP30 (which itself has no functional activity) to form a hexameric structure and therefore creating “Multimeric Proteins”, or
• by adding a cross-linking antibody called “TNF Ligands Enhancer” (Prod. No. AG-35B-0001).

CD40L (human) (multimeric) (rec.)

AG-40B-0010-C010                                                10 μg
AG-40B-0010-3010          MultiPack                 3 x 10 μg

CD40L (human) (multimeric) (rec.) (Certified Serum Grade)

AG-40B-0010CSG-C100                                      100 μg

• MultimericCD40L™ very effectively mimics the natural membrane-assisted aggregation of CD40L. It is the most potent alternative to activate CD40. No enhancer is required.

• MultimericCD40L™ is a potent B cell activator.

Literature References:
 • IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells: C. Werner-Favre, et al.; Eur. J. Immunol. 31, 243 (2001)

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