PANoptosis - Inflammatory Cell Death

Panoptosis

Programmed cell death plays a crucial role in development and host defense with an overlap and crosstalk between pyroptosisapoptosis and necroptosis in the same cell population, leading to the concept of total cell death called PANoptosisDuring PANoptosis activated by bacterial and viral triggers, inflammatory cell death occurs through the collective activation of pyroptosis, apoptosis and necroptosis, which can circumvent pathogen-mediated inhibition of individual death pathways. Molecules from the pyroptotic, apoptotic and necroptotic cell death pathways interact to form a single molecular complex termed the PANoptosome.

Recent studies by the lab of Prof. Kanneganti (St. Jude Children's Research Hospital, Memphis) identified the PANoptosome, a molecular platform triggering inflammatory cell death. PANoptotic stimuli (bacteria or virus) induce the formation of a PANoptosome complex with a number of pyroptotic, apoptotic and necroptotic molecules such as ZBP1, RIPK1, RIPK3, Caspase-1, Caspase-8, NLRP3, Asc and FADD under regulation of ZBP1, TAK1 and Caspase-6.

Literature References:

  1. Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis): S. Christgen, et al.; Front. Cell.Infect. Microbiol. 10, 237 (2020)



Most Trusted, Validated & Cited Antibodies for PANoptosis Research


AdipoGen Life Sciences is a leader in Inflammasome Research and provides the best and thoroughly validated and published antibodies for Apoptosis, Pyroptosis and Necroptosis Research.  

Product Name PID Product Description
anti-ZBP1, mAb (Zippy-1) AG-20B-0010

Recognizes human and mouse ZBP1.

anti-Asc, pAb (AL177) AG-25B-0006

Recognizes human and mouse Asc.

All AL177-related Products

anti-Caspase-1 (p20) (mouse), mAb (Casper-1) AG-20B-0042

Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.

All Casper-1-related Products

anti-Caspase-1 (p10) (mouse), mAb (Casper-2) AG-20B-0044

Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.

All Casper-2-related Products

anti-Caspase-1 (p20) (human), mAb (Bally-1) AG-20B-0048

Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.

All Bally-1-related Products

anti-Caspase-4 /11 (p20), mAb (Flamy-1) AG-20B-0060

Recognizes endogenous full-length protein and activated (p20) fragment of mouse and human caspase-4/11. Does not detect human Caspase-5.

All Caspase-11-related Products

anti-Caspase-8 (human), mAb (C15) AG-20B-0057 Recognizes the p18 subunit of human caspase-8.
anti-Caspase-8 (mouse), mAb (1G12) AG-20T-0137 Recognizes full-length and the p18 cleaved fragment of mouse caspase-8.
anti-Caspase-8 (mouse), mAb (3B10) AG-20T-0138 Recognizes full-length and the p18 cleaved fragment of mouse caspase-8.
anti-FLIP, mAb (Dave-2) AG-20B-0005 Recognizes an epitope (aa 1-200) present in both short (FLIPS) and long (FLIPL) splice variants of human and mouse FLIP.
anti-FLIP (human), mAb (NF6) AG-20B-0056 Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP. This antibody recognizes an epitope in the N-terminal DED region (aa1-194).
NEW anti-FADD (human), mAb (1C4) AG-20B-0080 Recognizes the C-terminus of human FADD only in its unphosphorylated form.
NEW anti-FADD (human), mAb (1C4) (Biotin) AG-20B-0080B Recognizes the C-terminus of human FADD only in its unphosphorylated form.
anti-NLRP3/NALP3, mAb (Cryo-2) AG-20B-0014

Recognizes mouse and human NLRP3/NALP3.

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