Inflammasome Research - From Innate to Adaptive Immunity - Mini-Catalog

• Caspase-1 Detection
• Standard Antibodies
• Priming & Activation
• NLRP3 Inhibitors/Activators
• Metabolic Regulation
• Microtubule Assembly
• Inflammasome/Pyroptosis Gasdermin D & E
• Flagellin & NLRC4
• Latest Insights

For an overview of AdipoGen Life Sciences' entire panel of Inflammasome Reagents please search this website.

Released - June 2023

Version with Weblinks - Released June 2023

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Innate Immunity - Focus Toll-like Receptors (TLR) Agonists - Mini-Catalog

• TLR Receptors Agonists: TLR1/TLR2; TLR3; TLR4/CD14; TLR5; TLR6/TLR12; TLR7; TLR7/8; TLR9; TLR11/12
• RIG-I-like Receptors & Cytosolic DNA Sensor Agonists: MDA5; STING
• TLR4 and TLR9 Antagonists: IAXO Compounds; iODNs
• NLRC3 – Negative Regulator of Innate Immunity

For an overview of AdipoGen Life Sciences' entire panel of Innate Immunity Reagents please search this website.

Released - September 2019

Version with Weblinks - Released November 2020

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Gasdermin D Signaling & Inflammasome Research - Insights

Includes a Unique Tool to Measure Pyroptosis!

• Gasdermin C-terminal Fragment Detection
• Gasdermin N-terminal Pore Formation Inhibition
• Inflammasome Detection
• Inflammasome Activation & Inhibition
• Inflammasome Priming

For more information visit AdipoGen Life Sciences' landing page Gasdermin Signaling.

Released - February 2019

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Key Inflammasome Research Tools - Product Flyer

• Unique Antibodies: NLRP3 mAb (Cryo-2); Asc pAb; Caspase-1 (p10) mAb; Caspase-1 (p20) mAb (Casper-1)
• Potent Activators: Monosodium urate (MSU), Nigericin
• Potent Inhibitors: MCC-950; Isoliquiritigenin; 3-Hydroxybutyric acid; Arglabin and much more

For an overview of AdipoGen Life Sciences' entire panel of Inflammasome Research Products please search this website.

Released - October 2022

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B-Xpander™ 2024 - Product Flyer

B-Xpander™ is a potent enhanced Multimeric human CD40L cytokine, for B cell activation, B cell expansion (proliferation) and cell therapy applications. In-house production using a proprietary protocol and a characterized and certified CHO cell line allows the supply of the most active Multimeric human CD40L proteins in GMP-like format.

Quality Features of B-Xpander™ include:
• Production in characterized and certified CHO cell line (for GMP-grade manufacturing)
• High Bioactivity tested by ELISA/Cell-based Assays
• Verified Purity & Homogeneity by SEC
• Low Endotoxin Levels
• Batch-to-Batch Consistency
• Animal-component free Production
• No cross-lining Reagents necessary

For more information about AdipoGen Life Sciences' B-Xpander™ visit www.bxpander.com.

Released - June 2024

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InVivoKines™ 2024 (2nd Edition) - Product Flyer

InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. InVivoKines™ are Fc-based fusion proteins using the Knobs-into-Holes (KIH) technology.

Quality Features of InVivoKines™ include:
• Native Conformation − Production in HEK 293 or CHO cells
• Production under Animal-Free Conditions
• High Bioactivity tested by ELISA/Cell-based Assays
• Verified Purity & Homogeneity by SEC
• Low Endotoxin Levels
• Batch-to-Batch Consistency

For an overview of AdipoGen Life Sciences' entire panel of InVivoKines™ visit www.invivokines.com.

Released - September 2024

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Immune Checkpoint Reagents: Focus on T Cells - Mini-Catalog

Cancer immunotherapy (also called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving the system's natural ability to fight cancer. Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. Inhibitory checkpoint molecules, such as CTLA-4, PD-1, PD-L1 or LAG-3 are targets for cancer immunotherapy due to their potential for use in multiple types of cancers.  AdipoGen Life Sciences offers a broad panel of immune checkpoint reagents, including recombinant proteins, antibodies and ELISA Kits. 

For an overview of AdipoGen Life Sciences' entire panel of Immune Checkpoint Reagents please search this website.

Released - March 2019

Version with Weblinks - Released November 2020

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TNF Superfamily - Key Cytokines in B & T cell Immuno-Regulation - Mini-Catalog

TNFSF/TNFRSF together with the CD28-B7 family are two major co-signal pathways in T cell activation. CD28, ICOS, GITR, 4-1BB and OX40 pathways co-stimulate T cell activation. CTLA-4, PD-1, BTLA and CD160 pathways co-inhibit T cell activation.

Includes:

For an overview of AdipoGen Life Sciences' entire panel of TNF Superfamily Reagents please search this website.

Released - June 2022

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Proteins with Enhanced Activity & Stability - Mini-Catalog

AdipoGen Life Sciences specializes in the development of recombinant proteins that show enhanced activity and long half-life, produced in mammalian cells. Using proprietary in-house technologies together with established and published technologies, we engineer, develop and produce an innovative panel of recombinant proteins for different research fields including Cell Therapy Research.

Includes:

For more information visit AdipoGen Life Sciences' landing page Proteins with Enhanced Activity & Stability.

Released - April 2023

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Advanced Immune Regulation Reagents - Product Flyer

AdipoGen Life Sciences offers a comprehensive panel of new and innovative products in the Immune Regulation Research Field. This product flyer gives an overview of unique and the newest antibodies, proteins, ELISA kits and small molecules developed by AdipoGen Life Sciences.

For an overview of  AdipoGen Life Sciences' entire panel of Immune Regulation Reagents please search this website.

Released - April 2019

Version with Weblinks - Released November 2020

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Autoimmune Disease Biomarkers APRIL & BAFF - Insights

• Highly Sensitive and Specific human BAFF and APRIL ELISA Kits
• Unique Blocking Antibodies for mouse BAFF and mouse APRIL
• Highly Active Multimeric Proteins
• Other Standard Antibodies for FACS and Functional Applications 

For more information visit AdipoGen Life Sciences' landing page Autoimmune Diseases Biomarkers.

Latest Update - October 2021

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Ancell Corporation - Monoclonal Antibodies Overview - Product Flyer

Ancell's extensive panel of human CD antibodies is produced by its experienced in-house development team. The products are purified and conjugated under optimized conditions and rigorously tested in cell lines and human samples. Most of the antibodies are variously labeled to perform in multiple applications, including flow cytometry, immunohistochemistry and immunofluorescence. Several antibodies have functional applications which may be used for activation, neutralization or blocking studies.

For an overview of the entire Ancell product portfolio please search this website.

Released  October 2022

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RevMAb Biosciences - Mutant-specific Rabbit Monoclonal Antibodies - Product Flyer

RevMAb Biosciences offers a broad panel of validated rabbit monoclonal antibodies that are specific for mutant targets and which are useful as diagnostic tools in cancer research. 

For more information visit our RevMAb Biosciences landing page.

Released - April 2021

RevMAb Biosciences - Histone H3 Mutation Antibodies - Product Flyer

Histone mutations are useful diagnostic tools in cancer research. RevMAb Biosciences offers a broad panel of validated histone H3 mutations specific rabbit monoclonal antibodies. 

For more information visit our RevMAb Biosciences landing page.

Released - April 2021

Obesity & Diabetes Research 2023 - Mini-Catalog
Focus: Crucial Investment in the Future of Health

• Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research
• White & Brown Fat Cells
• Adipokines / Obesity-related ELISA Kits, Antibodies & Proteins: Adiponectin, Nampt/Visfatin, RBP4, Vaspin, ZAG
• Insulin, Isthmin-1 and GLUTs
• Obesity & Immunometabolism: Small Molecules Modulators
• IL-1 Family & Inflammasomes in Metabolic Diseases
• IL-33 & Adipose Tissue Homeostasis: Oxidation-resistant Proteins, IL-33 Blocking Antibody, ST2 Antibody for FACS
• Obesity & Angiogenesis: Potent ANG-2 Blocking Antibody
• Batokines & WAT Browning & Thermogenesis Regulators
• Myokines & Exercise - Asprosin - IL-6 - FNDC5/Irisin & FNDC4 - GDF15 & GFRAL
• AMPK Modulators, PPAR Agonists, Leptin Sensitizers, Microbiota-related Reagent, Antidiabetic Peptides

For an overview of AdipoGen Life Sciences' entire panel of Obesity & Diabetes Products please search this website.

Updated Version - November 2023

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Immunometabolism Research - Focus Cell Metabolism & NAD⁺ Metabolism - Mini-Catalog

Immunometabolism is a research field that provides new insights into the dynamic cross-talk between the immune system (immunity) and metabolic processes of an organism (metabolism).

AdipoGen Life Sciences offers a broad range of Cell Metabolism and NAD⁺ Metabolism Reagents:
• Small Molecules Modulators of Glycolysis, TCA Cycle, Fatty Acid Oxidation, Fatty Acid Synthesis Pathway, Amino Acid Pathways
• Inhibitors of IDO1 and Nampt
• Biologically Active Enzymes: Human Arginase I / Human IDO1 Enzyme / Mouse Nampt

This Mini-Catalog includes a cell metabolism signaling wallchart with relevant small molecule inhibitors. 

For an overview of AdipoGen Life Sciences' entire panel of Immunometabolism Research Reagents please search this website.

Version with Weblinks - Released November 2020

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Erythroferrone (human) ELISA Kit - Insights
The only Specific & Sensitive Assay on the Market!

• High Specificity
• High Sensitivity
• High Reproducibility
• Tested & Validated with many Samples
• Swiss Quality Guarantee

For an overview of AdipoGen Life Sciences' panel of Iron Metabolism-related Products please search this website.

Released - May 2019

Version with Weblinks - Released November 2020

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Neuroscience Research - Mini-Catalog

AdipoGen offers a broad range of unique tools for neuroinflammation and neurodegeneration research. This includes a broad range of Irisin-related reagents, IL-33 reagents, the best inflammasomes research reagents to study the activation of neuroinflammation, posttranslational microtubule-specific antibodies, unique progranulin ELISA Kits and proteins, a broad range of immunometabolism reagents, biologically active Netrin-1 for axon outgrowth studies, many Neurochemicals, a selected range of neuronal dyes and stain, and many other reagents.
 
For an overview of AdipoGen Life Sciences' entire panel of Neuroscience Reagents please search this website.


Released - November 2022

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Progranulin - Marker of Neuroinflammation - Insights

NEW mAb/mAb-based Progranulin (human) ELISA Kit
• Highly Sensitive and Specific (see Validation Poster)!
• Reliable and Cost-effective 

STANDARD - Progranulin [PGRN] ELISA Kit
• Trusted Reproducible Results!
• Used to Determine Cut-Off values for FTLD!
• Cited in Hundreds of Scientific Publications!

TAG-FREE - Progranulin Recombinant Proteins
• Higher activity compared to tagged progranulins
• Suitable for in vitro and in vivo studies

For more information visit AdipoGen Life Sciences' landing page on Progranulin.

Released - January 2023 - Version with Weblinks

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Interleukin-33 - Insights
New Function of a Key Cytokine in Brain Development & Neurological Diseases

IL-33 is a nuclear-associated cytokine that is normally released by damaged or necrotic cells acting as an “alarmin”, an immediate indicator of tissue stress. IL-33 is a potent inducer of type 2 immune responses in the context of parasite infections and allergic asthma. New studies have also extended the biology of IL-33 with other functions: i) inducing brown and beige adipocyte thermogenesis and promoting insulin secretion by pancreatic islets; ii) facilitating Treg proliferation to suppress autoimmunity and to potentiate neurological recovery; and iii) exerting multiple roles in the brain.

For more information visit AdipoGen Life Sciences' landing page on Interleukin-33 (in process).

Released - January 2020

Version with Weblinks - Released November 2020

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COVID-19: Reagents for SARS-CoV-2/COVID-19 Research - Insights

• Blocking human ACE2 Antibody
• Soluble recombinant human ACE2 Protein, produced in mammalian cells (HEK 293)
• Recombinant SARS-CoV-2 RBD Domain
• ACE2 (human) ELISA Kit
• SARS-CoV-2 Neutralizing Antibodies Detection Kit
• Anti-SARS-CoV-2 Serological IgG Assay
• Anti-SARS-CoV-2 Screening Assay
• Small Molecule SARS-CoV-2 Infection Inhibitors/Modulators

For an overview of AdipoGen Life Sciences' entire panel of COVID-19/SARS-CoV-2 Reagents see COVID-19.

Released - September 2020 - Updated December 2020

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Reagents for SARS-CoV-2/COVID-19 Research - Product Flyer

Focus on:
• ACE2 (human) ELISA Kit
• SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit
• SARS-CoV-2 Neutralizing Antibodies Detection Kit
• SARS-CoV-2 Inhibitor Screening Assay
• anti-ACE2 (human), mAb (blocking) (AC384) (preservative free)
• Antiviral Compounds

For more information visit AdipoGen Life Sciences' landing page on COVID-19.

Released - July 2020

ELISA Kits for Key Biomarkers - Focusing on Emerging Research Fields - Mini-Catalog

AdipoGen Life Sciences offers a broad range of Biomarker Assays. This Mini-Catalog includes the standard ELISA Kits for Adiponectin | ANGPTL3 | ANGPTL6 | APRIL | BAFF | Caspase-1 | CD40L | DLK1 | GPX1 | GPX3 | IL-36β | IL-36γ | IL-36Ra | IL-37 | IL-38 | Irisin | Nampt/Visfatin | Periostin | Progranulin (new mAb/mAb) | RBP4 | Vaspin | Zinc-α Glycoprotein, and also new Assays for SARS-CoV-2 | ACE2 | ACBP | Asprosin | B7-H3 | CD40L | Erythroferrone | FGL-1 | FNDC4 | Gasdermin D & E | ICOSL | IL-1β  | PD-1 and PD-L1.

The Mini-Catalog also includes the Oxidative Stress Assays from JaICA.

AdipoGen Life Sciences and JaICA ELISA Kits allow reproducible results with low inter- and intra-assay variation, show high sensitivity and can be used for a broad range of sample types.

For an overview of the entire panel of "ELISA Kits" please search this website.

Released - January 2023 - Includes Product URLs

ELISA Kits - Biomarker Assays for Preclinical & Diagnostic Research - Product Flyer

AdipoGen Life Sciences ELISA Kits allow reproducible results with low inter- and intra-assay variation, show high sensitivity and can be used for a broad range of sample types.

For an overview of the entire panel of "ELISA Kits" please search this website.

Released - September 2023

Rare Antibiotics & Natural Products - Mini-Catalog

AdipoGen Life Sciences offers a broad panel of >500 natural products, from bacterial, fungal, marine and plant sources. This panel includes known active and well-characterized natural products in combination with unusual and difficult to isolate compounds, which are unique to AdipoGen Life Sciences. All compounds are structurally determined, purified and analytically validated. Included in this panel are key standard research antibiotics, rare metabolites/antibiotics with new chemical structures (often only described once in literature and afterward lost to research), or old already forgotten substances for lead drug research, seeking new “antibiotics” with a new mode of actions and new molecular targets. 

For an overview of AdipoGen Life Sciences' entire panel of Rare Antibiotics & Unique Natural Products please search this website.

Released - July 2024

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Chemodex - Fluorescent Reagents & Fine Chemicals - Mini-Catalog

Chemodex is a Swiss manufacturer of:

• Common and New Fluorescent Markers, Probes, Stains, Labels
• Cellular Sensors, Ion and pH Indicators
• Reactive Oxygen Species (ROS) Detection / Nitric Oxide Detection
• Cell Biology Dyes & Probes
• Molecular Biology & Analytical Reagents
• References Compounds (Pollutant & Pesticides)
• Quorum Sensing Reagents – Largest Panel
• Specialty Reagents, APIs & Building Blocks

Released - November 2022

Functional Antibodies - Mini-Catalog
Focus: Blocking, Neutralizing, Activation & Depletion & Recombinant Antibodies

Antibodies displaying an agonist or antagonist activity (functional grade antibodies (FuncAbs™)) are powerful tools for mimicking or blocking physiological functions in vitro and in vivo. Adipogen Life Sciences offers functional grade antibodies free of preservatives and tested for low endotoxin content and useful for activation, neutralizing or blocking studies, both in vitro or in vivo. Adipogen Life Sciences also offers recombinant monoclonal antibodies (RecMAbs™) generated by antibody phage display. An important attribute of the RecMAbs™ phage display approach is the ability to design selection strategies to generate antibodies with customized functions (FuncAbs™).

For an overview of AdipoGen Life Sciences' entire panel of Functional Antibodies please search this website.

Released - February 2018

Version with Weblinks - Released November 2020

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The Tubulin Code: Posttranslational Modifications of Tubulin - Insights

Tubulins and microtubules (MTs) are major substrates for Posttranslational modifications (PTMs). They include tyrosination/detyrosination, D2-tubulin formation, acetylation, phosphorylation, polyamination, ubiquitination, polyglutamylation and glycylation. All are important for wound healing, neurogenesis, immune response and cancer research.

For more information visit AdipoGen Life Sciences' landing page on The Tubulin Code.

Released - January 2020

Version with Weblinks - Released November 2020

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Manumycin A - Exosome Biogenesis Inhibitor

AdipoGen Life Sciences offers a broad range of exosome biogenesis modulators (e.g. Manumycin A), standard exosome markers (e.g. CD9, CD63, CD81) and exosomal capturing/sorting biomarkers (Tim-4).

Released - March 2024

AdipoGen Life Sciences & South Bay Bio - Mini-Catalog

AdipoGen Life Sciences & South Bay Bio offer a broad panel of reagents in the field of the Ubiquitin-Proteasome System (UPS).

• Highly Active Enzymes
• High Purity Proteasomes
• Cryptate-based TR-FRET Reagents
• High Active Proteasome Inhibitors
• Selective Proteasome Substrates/Probes

For an overview of the entire panel of "Ubiquitin-related Reagents" please search this website.

Released - August 2017