NAICONS and AdipoGen Life Sciences Partner on Commercializing NAICONS’ Rare Antibiotics and Natural Products on the Research Market

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LAG-3 - A Selective Immune Checkpoint

A new study from the lab of Taku Okazaki (Tokushima University, Japan) reveals how LAG-3 inhibits the activation of T cell response: it does not recognize MHC class II universally as previously thought, but instead recognizes selectively MHC class II proteins presenting only stably bound peptides. The same study shows that LAG does not compete CD4 for MHC-II interaction, but it blocks T cells by transducing inhibitory signals via its intracellular region.

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