anti-PSD-95 (palmitoylated), mAb (rec.) (PF11)

CHF 590.00
In stock
AG-27B-0021-C100100 µgCHF 590.00
 
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Product Details
Synonyms PSD95; Disks Large Homolog 4; DLG4; Postsynaptic Density Protein 95; Synapse-associated Protein 90; SAP90
Product Type Recombinant Antibody
Properties
Clone PF11
Isotype Human IgG2
Source/Host HEK 293 cells
Immunogen/Antigen Palmitoylated PSD-95.
Application Immunocytochemistry: 1/1000 dilution (fixed with methanol)
Immunohistochemistry: 1/500 dilution (fixed with acetone; does not work with paraformaldehyde)
Crossreactivity Human
Mouse
Rat
Specificity Recognizes human, mouse and rat palmitoylated PSD-95.
Purity ≥95% (SDS-PAGE)
Purity Detail Protein A-affinity purified.
Concentration 0.5 mg/ml
Formulation Liquid. In PBS containing 10% glycerol.
Other Product Data anti-PSD95 Palmitoylated, mAb (rec.) (PF11) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the human lgG2 Fc domain.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
PSD-95 is a member of proteins located at a specialized postsynaptic membrane region, called the postsynaptic density (PSD). PSD-95 is the most abundant scaffold protein specifically enriched in the PSD. It contains three PDZ domains, an SH3 domain and a guanylate kinase (GuK)-like domain. Through its PDZ domains, PSD-95 assembles various synaptic components at the PSD including intracellular signaling molecules (e.g. SynGAP and kalirin-7), ion channels (e.g. stargazin/AMPA receptors [AMPARs] and NMDA receptors) and cell adhesion molecules (e.g. neuroligin). PSD-95 plays a primary role in synaptic development and maturation and is regulated by palmitoylation at its N-terminal cysteine residues leading to its postsynaptic targeting. Palmitoylation of PSD-95 is triggered by DHHC2, a plasma membrane-inserted palmitoylating enzyme. Palmitoylated PSD-95 is almost exclusively localized at excitatory synapses in neurons.
Product References
  1. Local palmitoylation cycles define activity-regulated postsynaptic subdomains: Y. Fukata, et al.; J. Cell Biol. 202, 145 (2013)
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