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AdipoGen Life Sciences
(-)-Viriditoxin
170
CHF
CHF 170.00
In stock
AG-CN2-0471-C500500 µgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | (M)-Viriditoxin; SC-28762 |
| Product Type | Chemical |
| Properties | |
| Formula |
C34H30O14 |
| MW | 662.6 |
| CAS | 1381782-08-6 |
| Source/Host Chemicals | Isolated from fungus Aspergillus sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | GMCZVCXZGZGZPX-HOTGVXAUSA-N |
| Smiles | COC(=O)C[C@@H]1CC2=CC3=C(C(O)=CC(OC)=C3C3=C4C=C5C[C@@H](CC(=O)OC)OC(=O)C5=C(O)C4=C(O)C=C3OC)C(O)=C2C(=O)O1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antibiotic. Exhibits broad activity against Gram-positive bacteria.
- Bacterial cell division protein FtsZ inhibitor (IC50=8.2µg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0µg/ml).
- Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells.
- Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria.
Product References
- Viriditoxin production by Aspergillus viridi-nutans and related species: E.B. Lillehoj & M.S. Milburn; Appl. Microbiol. 26, 202 (1973)
- Metabolic products from Spicaria divaricata NRRL 5771: J. Jiu S. Mizuba; J. Antibiot. (Tokyo) 27, 760 (1974)
- Viriditoxin induces swelling and atpase by activation of calcium transport in liver mitochondria: D.T. Wong & R.L. Hamill; BBRC 71, 332 (1976)
- Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics: J. Wang, et al.; J. Biol. Chem. 278, 44424 (2003)
- Second-Generation Synthesis of (-)-Viriditoxin: C.I. Grove & J.T. Shaw; Synthesis 2012, 362 (2012)
- Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells: S. Kundu, et al.; Int. J. Oncol. 45, 2331 (2014)
- A twist of nature - the significance of atropisomers in biological systems: J.E. Smyth, et al.; Nat. Prod. Rep. 32, 1562 (2015)
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