Raptinal

CHF 45.00
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Product Details
Synonyms [9,9'-Bi-9H-fluorene]-9,9'-dicarboxaldehyde; NSC 610970
Product Type Chemical
Properties
Formula C28H18O2
MW 386.4
CAS 1176-09-6
Purity Chemicals ≥98% (NMR)
Appearance Beige solid.
Solubility Soluble in DMSO.
Identity Determined by 1H-NMR.
Other Product Data Note: Use fresh solutions. Cyclizes in water/acidic conditions.
InChi Key GLANOOJJBKXTMI-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Keep under inert gas.
Protect from moisture and oxygen.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis.
  • Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4μM indicating activity across a wide range of cell lines.
  • Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.
Product References
  1. A small molecule that induces intrinsic pathway apoptosis with unparalleled speed: R. Palchaudhuri, et al.; Cell Rep. 13, 2027 (2015)
  2. The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity: K.S. Schneider, et al.; Cell Rep. 21, 3846 (2017)
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