Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Raptinal
45
CHF
CHF 45.00
In stock
AG-CR1-2902-M0011 mgCHF 45.00
AG-CR1-2902-M0055 mgCHF 90.00
AG-CR1-2902-M02525 mgCHF 270.00
| Product Details | |
|---|---|
| Synonyms | [9,9'-Bi-9H-fluorene]-9,9'-dicarboxaldehyde; NSC 610970 |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H18O2 |
| MW | 386.4 |
| CAS | 1176-09-6 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Beige solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Note: Use fresh solutions. Cyclizes in water/acidic conditions. |
| InChi Key | GLANOOJJBKXTMI-UHFFFAOYSA-N |
| Smiles | O=CC1(C2(C=O)C3=C(C=CC=C3)C4=C2C=CC=C4)C5=C(C=CC=C5)C6=C1C=CC=C6 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Keep under inert gas. Protect from moisture and oxygen. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis.
- Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4μM indicating activity across a wide range of cell lines.
- Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.
- This caspase-3 activator induced Gasdermin-E (GSDME)-dependent pyroptosis in naive and therapy-resistant melanoma.
Product References
- A small molecule that induces intrinsic pathway apoptosis with unparalleled speed: R. Palchaudhuri, et al.; Cell Rep. 13, 2027 (2015)
- The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity: K.S. Schneider, et al.; Cell Rep. 21, 3846 (2017)
- Raptinal induces Gasdermin E-dependent pyroptosis in naïve and therapy-resistant melanoma: M. Vernon, et al.; Mol. Cancer Res. 20, 1811 (2022)
- Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis: E. Neuwirt, et al.; Sci. Signal. 16, 768 (2023)