AdipoGen Life Sciences

Raptinal

Name: Raptinal
Brand: AdipoGen Life Sciences
SKU: AG-CR1-2902
Price: 45.00 CHF
Availability: InStock

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AG-CR1-2902-M0011 mgCHF 45.00

AG-CR1-2902-M0055 mgCHF 90.00

AG-CR1-2902-M02525 mgCHF 260.00

Specifications / Handling

More Information
Product Details
Synonyms	[9,9'-Bi-9H-fluorene]-9,9'-dicarboxaldehyde; NSC 610970
Product Type	Chemical
Properties
Formula	C₂₈H₁₈O₂
MW	386.4
CAS	1176-09-6
Purity Chemicals	≥98% (NMR)
Appearance	Beige solid.
Solubility	Soluble in DMSO.
Identity	Determined by ¹H-NMR.
Other Product Data	Note: Use fresh solutions. Cyclizes in water/acidic conditions.
InChi Key	GLANOOJJBKXTMI-UHFFFAOYSA-N
Smiles	O=CC1(C2(C=O)C3=C(C=CC=C3)C4=C2C=CC=C4)C5=C(C=CC=C5)C6=C1C=CC=C6
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Keep under inert gas. Protect from moisture and oxygen.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis.
Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC₅₀ values between 0.7-3.4μM indicating activity across a wide range of cell lines.
Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.
This caspase-3 activator induced Gasdermin-E (GSDME)-dependent pyroptosis in naive and therapy-resistant melanoma.

Product-specific References

A small molecule that induces intrinsic pathway apoptosis with unparalleled speed: R. Palchaudhuri, et al.; Cell Rep. 13, 2027 (2015)
The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity: K.S. Schneider, et al.; Cell Rep. 21, 3846 (2017)
Raptinal induces Gasdermin E-dependent pyroptosis in naïve and therapy-resistant melanoma: M. Vernon, et al.; Mol. Cancer Res. 20, 1811 (2022)
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis: E. Neuwirt, et al.; Sci. Signal. 16, 768 (2023)
Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation: B.S. Saller, et al.; Immunity 58, 90 (2025)

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