AdipoGen Life Sciences

MCC950 . sodium salt

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AG-CR1-3615-M0011 mgCHF 40.00

AG-CR1-3615-M0055 mgCHF 65.00

AG-CR1-3615-M01010 mgCHF 100.00

AG-CR1-3615-M05050 mgCHF 330.00

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Specifications / Handling

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Product Details
Synonyms	MCC950; CP-456,773; CRID3; 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea
Product Type	Chemical
Properties
Formula	C₂₀H₂₃N₂NaO₅S
MW	426.5
CAS	256373-96-3
Purity Chemicals	≥97% (HPLC)
Appearance	Off-white crystalline solid.
Solubility	Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml).
Identity	Determined by ¹H-NMR.
InChi Key	SNIGCXULUAXYGW-UHFFFAOYSA-N
Smiles	[NaH].CC(C)(O)C1=COC(=C1)S(=O)(=O)NC(=O)NC1=C2CCCC2=CC2=C1CCC2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Scientific Background Information

Product Description

Potent, selective and orally available NLRP3 inflammasome inhibitor.
Blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3.
Prevents oligomerization of ASC in cells stimulated with LPS and nigericin.
Active in vivo, blocking the production of IL-1β and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome (CAPS). Also active in ex vivo samples from individuals with Muckle-Wells syndrome.
Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.

Product-specific References

Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing: R.E. Laliberte, et al.; J. Biol. Chem. 278, 16567 (2003) [PMID: 12624100]
Novel synthesis of 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methylethyl)furan-2-sulfonyl]urea, an antiinflammatory agent: F.J. Urban, et al.; Synth. Commun. 33, 2029 (2003) [DOI: 10.1081/SCC-120021029]
The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes: R.C. Coll, et al.; PLoS One 6, e29539 (2011) [PMC3245271]
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases: R.C. Coll, et al.; Nat. Med. 21, 248 (2015) [PMC4392179]
Taming the inflammasome: M. Levy, et al.; Nat. Med. 21, 213 (2015) [PMID: 25742454]
The Nlrp3 inflammasome admits defeat: C.J. Gross & O. Gross; Trends Immunol. 36, 323 (2015) [PMID: 25991463]

Additional References using AdipoGen AG-CR1-3615:
A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis: R. Kang, et al.; Autophagy 12, 2374 (2016) [PMC5173260]
P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy: M.G. Khalafalla, et al.; J. Biol. Chem. 292, 16626 (2017) [PMC5633125]
Inhibition of the NOD-like receptor protein 3 inflammasome Is protective in juvenile influenza A virus infection: B.M. Coates, et al.; Front. Immunol. 8, 782 (2017) [PMC5502347]
MCC950, the selective NLRP3 inflammasome inhibitor protects mice against traumatic brain injury: S. Ismael, et al.; J. Neurotrauma 35,1294 (2017) [PMC5962912]
Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation: Y.K. Kim, et al.; Evid. Compl. Altern. Med. 6346734 (2018) [PMC5822850]
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice: A.P. Perera, et al.; Sci. Rep. 8, 8618 (2018) [PMC5988655]
α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1–42-stimulated murine astrocytes: T. Ebrahimi, et al.; J. Neuroinfl. 15, 282 (2018) [PMC6158809]
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients: F. Magnotti, et al.; EMBO Mol. Med. 11, e10547 (2019) [PMC6835204]
Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes: W.J. Pandori, et al.; PLoS Pathog. 15, e1007923 (2019) [PMC6730955]
A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis: R. Kang, et al.; Autophagy 12, 2374 (2016) [PMC5173260]
Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition: U.T. Tran & T. Kitami; Commun. Biol. 2, 2 (2019) [PMC6318214]
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR: M. Deng, et al.; J. Exp. Med. 216, 2838 (2019) [PMC6888982]
Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis: M. Murakami, et al.; Reprod. Biol. Endocrinol. 20, 58 (2022) [PMC8966161]
Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome: T. Karasawa, et al.; eLife 11, e75166 (2022) [PMC9177154]
Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism: F. Magnotti et al.; Cell Rep. 41, 111472 (2022) [PMC9626387]
Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis: J. Hettwer, et al.; Cardiovasc. Res. 117, 2778 (2022) [PMC9586563]
Adipolin protects against renal injury via PPARα-dependent reduction of inflammasome activation: L. Fang, et al.; iScience 26, 106591 (2023) [PMC10214396]
Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice: A.J.T. Bosch, et al.; Part. Fibre Toxicol. 20, 25 (2023) [PMC10316612]
Chemical screens for particle-induced macrophage death identifies kinase inhibitors of phagocytosis as targets for toxicity: U.T. Tran & T. Kitami; J. Nanobiotechnology 22, 621 (2024) [PMC11472441]
Rickettsia disrupts and reduces endothelial tight junction protein zonula occludens-1 in association with inflammasome activation: L.R. Velatooru, et al.; Infect. Immun. 93, e00468-24 (2025) [PMC11784141]
Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation: B.S. Saller, et al.; Immunity 58, 90 (2025) [PMID: 39571574]
NLRP3 inflammasome partially mediates genotoxic E. coli infection in lean but not in genetically obese mice: P. Floch, et al.; iScience 29, 116674 (2026) [PMC13380450]

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