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AdipoGen Life Sciences
Arglabin
95
CHF
CHF 95.00
In stock
AG-CN2-0458-M0011 mgCHF 95.00
AG-CN2-0458-M0055 mgCHF 380.00
| Product Details | |
|---|---|
| Synonyms | Arglabine |
| Product Type | Chemical |
| Properties | |
| Formula |
C15H18O3 |
| MW | 246.3 |
| CAS | 84692-91-1 |
| Source/Host Chemicals | Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | UVJYAKBJSGRTHA-CUZKYEQNSA-N |
| Smiles | [H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anticancer compound.
- Farnesyltransferase inhibitor.
- Potent anti-inflammatory agent.
- NF-κB inhibitor.
- Inflammasome inhibitor.
- Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
Product References
- In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall: C. Bottex-Gauthier, et al.; Biotechnol. Ther. 4, 77 (1993)
- Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase: T.E. Shaikenov, et al.; Oncol. Rep. 8, 173 (2001)
- Biomimetic semisynthesis of arglabin from parthenolide: J.D. Zhai, et al.; JOC 77, 7103 (2012)
- Synthesis and biological evaluation of antitumor-active arglabin derivatives: R. Csuk, et al.; Arch Pharm. 345, 215 (2012)
- Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells: Q.Q. Jia, et al.; Molecules 18, 13061 (2013)
- Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin: S.H. Lone & K.A. Bhat; THL 56, 1908 (2015)
- Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)
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