AdipoGen Life Sciences

Arglabin

Name: Arglabin
Brand: AdipoGen Life Sciences
SKU: AG-CN2-0458
Price: 80.00 CHF
Availability: InStock

As low as CHF 80.00

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AG-CN2-0458-M0011 mgCHF 80.00

AG-CN2-0458-M0055 mgCHF 320.00

Specifications / Handling

More Information
Product Details
Synonyms	Arglabine
Product Type	Chemical
Properties
Formula	C₁₅H₁₈O₃
MW	246.3
CAS	84692-91-1
Source/Host Chemicals	Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora.
Purity Chemicals	≥95% (HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in dry DMSO, 100% ethanol or methanol. Insoluble in water.
Identity	Determined by ¹H-NMR.
InChi Key	UVJYAKBJSGRTHA-CUZKYEQNSA-N
Smiles	[H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
Safety Data Sheet	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Anticancer compound.
Farnesyltransferase inhibitor.
Potent anti-inflammatory agent.
NF-κB inhibitor.
Inflammasome inhibitor.
Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.

Product-specific References

In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall: C. Bottex-Gauthier, et al.; Biotechnol. Ther. 4, 77 (1993)
Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase: T.E. Shaikenov, et al.; Oncol. Rep. 8, 173 (2001)
Biomimetic semisynthesis of arglabin from parthenolide: J.D. Zhai, et al.; JOC 77, 7103 (2012)
Synthesis and biological evaluation of antitumor-active arglabin derivatives: R. Csuk, et al.; Arch Pharm. 345, 215 (2012)
Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells: Q.Q. Jia, et al.; Molecules 18, 13061 (2013)
Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin: S.H. Lone & K.A. Bhat; THL 56, 1908 (2015)
Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)

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