BAY 11-7082

CHF 90.00
In stock
AG-CR1-0013-M01010 mgCHF 90.00
AG-CR1-0013-M05050 mgCHF 360.00
More Information
Product Details
Synonyms (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
Product Type Chemical


MW 207.3
CAS 19542-67-7
Purity Chemicals ≥99% (NMR)
Appearance White to off-white crystalline solid.
Solubility Soluble in DMSO, 100% ethanol, dichloromethane or ethyl acetate; insoluble in water.
Smiles CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)\C=C\C#N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep under inert gas.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • IκBα kinase inhibitor [1].
  • NF-κB inhibitor [1].
  • Potential anti-inflammatory agent [1].
  • Apoptosis inducer [2].
  • Inhibits the release of proinflammatory cytokines [3].
  • NLRP3 inflammasome inhibitor [4]. Reduces ATPase activity of the NLRP3 inflammasome.
  • Inhibits platelet aggregation [5].
Product References
  1. Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997) 
  2. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells: N. Mori, et al.; Blood 100, 1828 (2002) 
  3. Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro: M. Lappas et al.; Endocrinology 146, 1491 (2005) 
  4. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome: C. Juliana, et al.; J. Biol. Chem. 285, 9792 (2010)
  5. A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations: H.S. Lee, et al.; Eur. J. Pharmacol. 627, 85 (2010)
  6. The impact of α-Lipoic acid on cell viability and expression of nephrin and ZNF580 in normal human podocytes: U. Leppert, et al.; Eur. J. Pharmacol. 810, 1 (2017)
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