Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
GeA-69
60
CHF
CHF 60.00
In stock
AG-CR1-3706-M0011 mgCHF 60.00
| Product Details | |
|---|---|
| Synonyms | N-(2-(9H-Carbazol-1-yl)phenyl)acetamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H16N2O |
| MW | 300.4 |
| CAS | 2143475-98-1 |
| Purity Chemicals | ≥95% |
| Appearance | Off-white to light brownish solid. |
| Solubility | Soluble in DMSO (2mg/ml). |
| InChi Key | LDPDVNYCIOHPGF-UHFFFAOYSA-N |
| Smiles | O=C(C)NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
-
Potent, selective, allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP-14 M2) (Kd=0.86µM, ITC (isothermal titration calorimetry) assay). PARP-14 is an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer.
-
Engages PARP-14 MD2 in intact cells displaces adenosine diphosphate ribose (ADPR) from PARP-14 M2 and prevents recruitment of the PARP-14 M2 to DNA damage sites.
Product References
- Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14: M. Schuller, et al.; ACS Chem. Biol. 12, 2866 (2017)
- Discovery of a novel allosteric inhibitor scaffold for polyadenosinediphosphate-ribose polymerase 14 (PARP14) macrodomain 2: M. Moustakim, et al.; Bioorg. Med. Chem. 26, 2965 (2018)
Related Products
