GeA-69

CHF 60.00
In stock
AG-CR1-3706-M0011 mgCHF 60.00
More Information
Product Details
Synonyms N-(2-(9H-Carbazol-1-yl)phenyl)acetamide
Product Type Chemical
Properties
Formula

C20H16N2O

MW 300.4
CAS 2143475-98-1
Purity Chemicals ≥95%
Appearance Off-white to light brownish solid.
Solubility Soluble in DMSO (2mg/ml).
InChi Key LDPDVNYCIOHPGF-UHFFFAOYSA-N
Smiles O=C(C)NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent, selective, allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP-14 M2) (Kd=0.86µM, ITC (isothermal titration calorimetry) assay). PARP-14 is an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer.

  • Engages PARP-14 MD2 in intact cells displaces adenosine diphosphate ribose (ADPR) from PARP-14 M2 and prevents recruitment of the PARP-14 M2 to DNA damage sites.

Product References
  1. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14: M. Schuller, et al.; ACS Chem. Biol. 12, 2866 (2017)
  2. Discovery of a novel allosteric inhibitor scaffold for polyadenosinediphosphate-ribose polymerase 14 (PARP14) macrodomain 2: M. Moustakim, et al.; Bioorg. Med. Chem. 26, 2965 (2018)
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