AZ9482

CHF 108.00
In stock
SYN-3046-M0011 mgCHF 108.00
SYN-3046-M0055 mgCHF 227.00
SYN-3046-M01010 mgCHF 347.00
SYN-3046-M05050 mgCHF 1'065.00
SYN-3046-M100100 mgCHF 1'784.00
 
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Product Details
Synonyms 2-(4-(3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)nicotinonitrile
Product Type Chemical
Properties
Formula C26H22N6O2
MW 450.5
CAS 1825345-33-2
Purity Chemicals ≥95%
Appearance Solid.
Solubility Soluble in DMSO or ethanol.
Declaration Manufactured by SynKinase.
Other Product Data Target: PARP | Kinase Group: N/A | Substrate: N/A

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Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key ZDDPBFWHZOJFHF-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
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Product Specification Sheet
Datasheet Download PDF
AZ9482 is a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity in HeLa cells (EC50 < 18nM). AZ9482 also showed a 3nM GI50 in the DLBCL cell line OCI-LY-19 in a 3-day AlamarBlue assay. Consistent with published siRNA knockdown experiments, AZ9482 was a 9nM enzyme inhibitor of tankyrase 1 (TNKS1).
Product References
  1. Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering: J.W. Johannes, et al.; Bioorg. Med. Chem. Lett. 25, 5743 (2015)
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