1,5-Isoquinolinediol

CHF 35.00
In stock
AG-CR1-0024-M0055 mgCHF 35.00
AG-CR1-0024-M02525 mgCHF 80.00
AG-CR1-0024-M100100 mgCHF 240.00
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Product Details
Synonyms 5-Hydroxy-1(2H)-isoquinolinone; 1,5-Dihydroxyisoquinoline
Product Type Chemical
Properties
Formula

C9H7NO2

MW 161.2
CAS 5154-02-9
Purity Chemicals ≥98% (NMR)
Appearance White to off-white solid.
Solubility Soluble in DMSO (20mg/ml), DMF (20mg/ml), ethanol (10mg/ml) or methanol (5mg/ml). Insoluble in water.
InChi Key LFUJIPVWTMGYDG-UHFFFAOYSA-N
Smiles OC1=CC=CC2=C(O)N=CC=C12
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Protect from light.
Use/Stability Stable for at least 2 years after receipt when stored at +4°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • PARP-1 inhibitor [1]. 
  • Neuroprotectant [2].
  • Blocks nitric oxide-induced neuronal toxicity [2].
  • Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor [3]. 
  • Stimulates homologous recombination [4]. 
Product References
  1. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992)
  2. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994)
  3. Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006)
  4. 1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003)
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