Fc (human):OX40L, Soluble (human) (rec.)
|Synonyms||CD252; CD134L; OX40 Ligand; TNFSF4; Tumor Necrosis Factor Superfamily Member 4; TAX Transcriptionally-activated Glycoprotein 1; TXGP1; Gp34|
|Source/Host||HEK 293 cells|
|Sequence||The extracellular domain of human OX40L (aa 50-183) is fused at the N-terminus to the Fc portion of human IgG1.|
|Specificity||Binds to human OX40 [CD134].|
|Biological Activity||Activates T cell proliferation.|
|Endotoxin Content||<0.01EU/μg purified protein (LAL test; Lonza).|
|Concentration||0.1mg/ml after reconstitution.|
|Reconstitution||Reconstitute with 100μl sterile water.|
|Formulation||Lyophilized. Contains PBS.|
|Other Product Data||
UniProt link P23510: OX40L (human)
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
PBS containing at least 0.1% BSA should be used for further dilutions.
Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
OX40L [CD252; TNFSF4] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its receptor OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. Fc (human):OX40L, Soluble (human) (rec.) is a high activity construct in which two trimeric OX40L ligands are artificially linked via the Fc domain of human immunoglobulin.