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Fc (human):OX40L, Soluble (human) (rec.)
230
CHF
CHF 230.00
In stock
AG-40B-0172-C01010 µgCHF 230.00
AG-40B-0172-30103 x 10 µgCHF 455.00
| Product Details | |
|---|---|
| Synonyms | CD252; CD134L; OX40 Ligand; TNFSF4; Tumor Necrosis Factor Superfamily Member 4; TAX Transcriptionally-activated Glycoprotein 1; TXGP1; Gp34 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of human OX40L (aa 50-183) is fused at the N-terminus to the Fc portion of human IgG1. |
| Crossreactivity | Human |
| Specificity |
Binds to human OX40 [CD134]. |
| Biological Activity |
Activates T cell proliferation. |
| MW | ~50kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test). |
| Concentration | 0.1mg/ml after reconstitution. |
| Reconstitution | Reconstitute with 100μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Protein Negative Control | |
| Other Product Data |
UniProt link P23510: OX40L (human) |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
OX40L [CD252; TNFSF4] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its receptor OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. Fc (human):OX40L, Soluble (human) (rec.) is a high activity construct in which two trimeric OX40L ligands are artificially linked via the Fc domain of human immunoglobulin.
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