AdipoGen Life Sciences

OX40 (human):Fc (human) (rec.)

CHF 215.00

In stock

AG-40B-0014-C05050 µgCHF 215.00

AG-40B-0014-30503 x 50 µgCHF 430.00

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Product Details
Synonyms	TNFRSF 4; Tumor Necrosis Factor Receptor Superfamily Member 4; CD134
Product Type	Protein
Properties
Source/Host	HEK 293 cells
Sequence	Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity	Human Mouse
Specificity	Binds to human and mouse OX40L.
Biological Activity	Blocks T cell proliferation induced by CD134L.
MW	~70kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.01EU/μg purified protein (LAL test; Lonza).
Concentration	1mg/ml after reconstitution.
Reconstitution	Reconstitute with 50μl sterile water.
Formulation	Lyophilized. Contains PBS.
Protein Negative Control	Fc (human) IgG1 Control (rec.)
Other Product Data	UniProt link P43489: CD134 (human) (precursor)
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Centrifuge lyophilized vial before opening and reconstitution.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.

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