CD134 [OX40] (human) (rec.) (His)
|Synonyms||OX40; Tumor Necrosis Factor Receptor Superfamily Member 4; TNFRSF4; ACT35; TXGP1L|
|Sequence||Human CD134 (aa 29-216) is fused at the C-terminus to a His-tag.|
|Endotoxin Content||<0.1EU/μg protein (LAL test; Lonza).|
|Reconstitution||Reconstitute in sterile water not less than 100μg/ml, which can then be further diluted to other aqueous solutions.|
|Formulation||Lyophilized from a concentrated sterile solution containing 50mM Tris-HCl buffer (pH 8.0) and 500mM NaCl.|
|Other Product Data||NCBI reference NP_003318.1: CD134 (human)|
|Declaration||Manufactured by Chimerigen.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Stable for at least 1 year after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
|Product Specification Sheet|
CD134 (OX40) is a T cell activation antigen structurally belonging to a lymphocyte-specific subgroup of the nerve growth factor and tumor necrosis factor receptor superfamily, which also includes the T cell antigen CD27, B cell antigen CD40, FAS antigen and the T cell activation antigen 4-1BB. The human CD134 protein is expressed only on activated CD4+ T blasts, and its ligand has been identified as gp34. Interactions between CD134 and its ligand in vivo are necessary for the differentiation of activated B cells into highly immunoglobulin-producing cells, however not involved in other pathways of antigen-driven differentiation of B cells such as development of memory cells in the germinal centers. In addition, the CD134 and gp34 system directly mediate adhesion of activated T cells to vascular endothelial cells, and contribute to growth stimulation of the virus-infected T cells.