IL-36β (human) Matched Pair Detection Set

CHF 750.00
In stock
AG-46B-0009-KI011 SetCHF 750.00
Reagents for 5 x 96-well plates
 
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Product Details
Synonyms Interleukin-36β Interleukin-1 Family Member 8; IL-1F8
Product Type Set
Properties
Application Set Quantitative ELISA
Specificity Detects human IL-36β in cell culture supernatant.
Crossreactivity Human
Quantity Contains sufficient materials to run ELISAs on 5 x 96-well plates.
Sensitivity 10 pg/ml
Range 15.6 to 1000 pg/ml
Sample Type Cell Culture Supernatant
Assay Type Sandwich
Detection Type Colorimetric
Kit Contains 1 vial standard protein (100ng) (lyophilized) [STD]
1 vial coating antibody (270μl) [COAT]
1 vial detection antibody (60μl) [DET]
1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
Shipping and Handling
Shipping BLUE ICE
Short Term Storage -20°C
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
Manual Download PDF
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
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