IL-36 gamma (aa 13-164) (mouse) (recombinant protein) (Flag)

Specifications / Handling

More Information
Product Details
Synonyms	Interleukin-36γ; Interleukin-1 Family Member 9; IL-1F9
Product Type	Protein
Properties
Source/Host	E. coli
Sequence	Mouse IL-36γ (aa Gly13-Ser164) is fused at the C-terminus to a FLAG^®-tag.
Crossreactivity	Mouse
Biological Activity	Induces secretion of IL-6 in BMDCs.
MW	~17kDa
Purity	≥95% (SDS-PAGE)
Endotoxin Content	<0.01EU/μg purified protein (LAL test; Lonza).
Concentration	0.1mg/ml after reconstitution.
Reconstitution	Reconstitute with 100μl sterile water.
Formulation	Lyophilized. Contains PBS.
Other Product Data	Uni-Prot link Q8R460 : Interleukin-36 γ
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability	Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

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IL-36γ (aa 13-164) (mouse) (rec.) (FLAG)