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AdipoGen Life Sciences
Glyburide (USP)
40
CHF
CHF 40.00
In stock
AG-CR1-3613-G0011 gCHF 40.00
AG-CR1-3613-G0055 gCHF 65.00
AG-CR1-3613-G01010 gCHF 110.00
| Product Details | |
|---|---|
| Synonyms | Diabeta; Glibenclamide |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H28ClN3O5S |
| MW | 494.0 |
| Merck Index | 14: 4478 |
| CAS | 10238-21-8 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol (gentle warming). |
| InChi Key | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| Smiles | COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antidiabetic compound.
- Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1).
- Causes cell membrane depolarization and opening of voltage-dependent calcium channel.
- Increases intracellular calcium and stimulates insulin secretion in β cells
- NLRP3 inflammasome inhibitor.
- Broad-spectrum ATP-binding cassette (ABC) transporter inhibitor.
- Shown to have anti-leishmanial activity.
- Potential inhibitor of collagenases.
Product References
- Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects: J.M. Feldman; Pharmacotherapy 5, 43 (1985)
- The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells: H. Schmid-Antomarchi, et al.; J. Biol. Chem. 262, 15840 (1987)
- Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels: M. Fosset, et al.; J. Biol. Chem. 263, 7933 (1988)
- Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator: C.M. McNicholas, et al.; PNAS 93, 8083 (1996)
- The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells: L. Payen, et al.; Br. J. Pharmacol. 132, 778 (2001)
- Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis: X. Serrano-Martin, et al.; Antimicrob. Agents Chemother. 50, 4214 (2006)
- CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three: P. Melin, et al.; Biochim. Biophys. Acta 1768, 2438 (2007)
- Glyburide inhibits the Cryopyrin/Nalp3 inflammasome: M. Lamkanfi, et al.; J. Cell. Biol. 187, 61 (2009)
- Glyburide in treating malignant cerebral edema. Blocking sulfonyl urea one (SUR1) receptors: T.V. Pallan & I. Ahmed; J. Vasc. Interv. Neurol. 7, 23 (2014)
- In vitro biological evaluation of glyburide as potential inhibitor of collagenases: V.L. Bodiga, et al.; Int. J. Biol. Macromol. 70, 187 (2014)
- NLRP3 inflammasome activation is essential for paraquat-induced acute lung injury: Z. Liu, et al.; Inflammation 38, 433 (2015)
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