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AdipoGen Life Sciences
CD137L, Soluble (mouse) (rec.)
420
CHF
CHF 420.00
In stock
AG-40A-0020Y-C05050 µgCHF 420.00
Figure 1: mCD137L-FLAG® binding to CD137 transfected cells.
HEK 293 cells were transiently transfected with a construct encoding full-length mouse CD137. At 48hrs after transfection, the transfectants were incubated with 0.5 or 5μg/ml CD137L, Soluble (mouse) (rec.) (Prod. No. AG-40A-0020Y) and followed by flow cytometry analysis with anti-FLAG® M2-FITC.
HEK 293 cells were transiently transfected with a construct encoding full-length mouse CD137. At 48hrs after transfection, the transfectants were incubated with 0.5 or 5μg/ml CD137L, Soluble (mouse) (rec.) (Prod. No. AG-40A-0020Y) and followed by flow cytometry analysis with anti-FLAG® M2-FITC.
| Product Details | |
|---|---|
| Synonyms | 4-1BBL; TNFSF9 |
| Product Type | Protein |
| Properties | |
| Source/Host | HEK 293 cells |
| Sequence |
The extracellular domain of mouse CD137L (aa 104-309) is fused at the N-terminus to a FLAG®-tag. |
| Crossreactivity | Mouse |
| Specificity |
Binds to mouse CD137. |
| MW | ~40kDa (SDS-PAGE) |
| Purity | ≥95% (SDS-PAGE) |
| Endotoxin Content | <0.01EU/μg purified protein (LAL test; Lonza). |
| Reconstitution | Reconstitute with 50μl sterile water. |
| Formulation | Lyophilized. Contains PBS. |
| Other Product Data |
UniProt link P41274: CD137L (mouse) FLAG is a registered trademark of Sigma-Aldrich Co. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
| Use/Stability |
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
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