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AdipoGen Life Sciences
Asperphenamate
120
CHF
CHF 120.00
In stock
AG-CN2-0171-C250250 µgCHF 120.00
AG-CN2-0171-M0011 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | Anabellamide; Asjanin; Auranamide; NSC 306231; N-Benzoyl-phenylalanine-2-benzoylamino-3-phenylpropyl ester |
| Product Type | Chemical |
| Properties | |
| Formula |
C32H30N2O4 |
| MW | 506.6 |
| CAS | 63631-36-7 |
| Source/Host Chemicals | Isolated from Aspergillus sp. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in ethanol, methanol or DMSO. |
| InChi Key | CVULDJMCSSACEO-FQLXRVMXSA-N |
| Smiles | O=C(OC[C@@H](CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1)[C@@H](CC1=CC=CC=C1)NC(=O)C1=CC=CC=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anticancer compound.
- Cytotoxic against human breast cancer cells.
- Induces autophagic cell death in MCF-7 cells.
- Moderate radical scavenger.
- Weak acetylcholinesterase (AChE) inhibitor.
- Shows moderate trypanocidal activity.
Product References
- Two metabolites from Aspergillus flavipes: A.M. Clark, et al.; Lloyda 40, 146 (1977)
- Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis: P.W. Wu, et al.; Chem. Pharm. Bull. 52, 345 (2004)
- A new method for asperphenamate synthesis and its antimicrobial activity evaluation: A.M. Pomini, et al.; Nat. Prod. Res. 20, 537 (2006)
- Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine: L. Yuane, et al.; Chin. Chem. Lett. 21, 155 (2010)
- JNK-dependent Atg4 upregulation mediates asperphenamate derivative BBP-induced autophagy in MCF-7 cells: Y. Li, et al.; Toxicol. Appl. Pharmacol. 263, 21 (2012)
- Two new Penicillium species Penicillium buchwaldii and Penicillium spathulatum, producing the anticancer compound asperphenamate: J.C. Frisvad, et al.; FEMS Microbiol. Lett. 339, 77 (2013)
- In vitro acetylcholinesterase activity of peptide derivatives isolated from two species of Leguminosae: C.Q. Alves, et al.; Pharm. Biol. 51, 936 (2013)
- Antioxidant activity of compounds isolated from the root woods of Erythrina droogmansiana: A.J.G. Yaya, et al.; Int. J. Pharm. Sci. Drug Res. 6, 160 (2014)
- Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae): N.J. Nwodo, et al.; Molecules 19, 5470 (2014)
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