Fc (human):Dectin-1 (mouse) (rec.)

Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes β-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes α-mannans and transduces its signal through association with the ITAM-containing Fc receptor γ-chain. Dectin-1 controls fungal infection by sensing β-glucans and by mounting a Th17-mediated immune responses. Dectin-1 seems to detect also non-fungal ligands such as invertebrate tropomyosin. Dectin-1 by binding to non-fungal ligands controls type 2 immunity in the lungs in response to the dust mite aeroallergen through the regulation of IL-33-driven IL-13 production from innate lymphoid cells.