AG-CR1-3648-M100100 mgCHF 65.00
AG-CR1-3648-G0011 gCHF 110.00
|Synonyms||Fluocyanobenpyrazole; Termidor; 5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethanesulfinyl)-1H-pyrazole-3-carbonitrile|
|Purity Chemicals||≥98% (NMR)|
|Appearance||White to yellow solid.|
|Solubility||Soluble in DMSO, methanol, ethanol or acetone. Insoluble in water.|
|Shipping and Handling|
|Short Term Storage||+20°C|
|Long Term Storage||+4°C|
|Use/Stability||Stable for at least 2 years after receipt when stored at +4°C.|
|Product Specification Sheet|
- Alzheimer inducing agent (Alzheimerogen).
- Potent GABA receptor α-4 subunit and β-3 subunit inhibitor.
- Broad-range insecticide. Blocks GABA A-gated chloride channels and glutamate-activated chloride channels (GluCls) in the central nervous system, resulting in overexcitation of the insects nervous system and muscles.
- Induces oxidative stress in mouse kidney and brain.
- Increases CYP1A1, CYP2B6, CYP3A4 and CYP3A5 transcript, protein and enzyme activity levels.
- Action of Phenylpyrazole Insecticides at the GABA-Gated Chloride Channel: L.M. Cole, et al.; Pestic. Biochem. Physiol. 46, 47 (1993)
- Actions of the insecticide fipronil, on dieldrin-sensitive and -resistant GABA receptors of Drosophila melanogaster: A.M. Hosie, et al.; Br. J. Pharmacol. 115, 909 (1995)
- Ion channels: molecular targets of neuroactive insecticides: V. Raymond-Delpech, et al.; Invert. Neurosci. 5, 119 (2005)
- Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals: T. Narahashi, et al.: Pestic. Biochem. Physiol. 97, 149 (2010)
- Fipronil induced oxidative stress in kidney and brain of mice: protective effect of vitamin E and vitamin C: P.C. Badgujar, et al.; Pestic. Biochem. Physiol. 118, 10 (2015)
- Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration: B.L. Pearson, et al.; Nat. Commun. (2015)
- Specific triazine herbicides induce amyloid-β42 production: E. Portelius, et al.; J. Alzheimers Dis. 54, 1593 (2016)
- Impact of environmental chemicals on the transcriptome of primary human hepatocytes: Potential for health effects: R.D. Mitchell, et al.; J. Biochem. Mol. Toxicol. 30, 375 (2016)